Search Results

Overview

Uniprot IDP30050
Protein NameLarge ribosomal subunit protein uL11
Gene NameRPL12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
4 ****MPPKFDPNEIK
40 GPLGLSPKKVGDDIA
41 PLGLSPKKVGDDIAK
54 AKATGDWKGLRITVK
86 ALIIKALKEPPRDRK
99 RKKQKNIKHSGNITF

Function

Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680)

Protein Sequence

10 MPPKFDPNEI 20 KVVYLRCTGG 30 EVGATSALAP 40 KIGPLGLSPK 50 KVGDDIAKAT 60 GDWKGLRITV 70 KLTIQNRQAQ 80 IEVVPSASAL 90 IIKALKEPPR 100 DRKKQKNIKH 110 SGNITFDEIV 120 NIARQMRHRS 130 LARELSGTIK 140 EILGTAQSVG 150 CNVDGRHPHD 160 IIDDINSGAV ECPAS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0022625 cytosolic large ribosomal subunit
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0014069 postsynaptic density
Molecular Function GO:0070180 large ribosomal subunit rRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:1901740 negative regulation of myoblast fusion
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0006412 translation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.