Search Results
Overview
| Uniprot ID | P30085 |
|---|---|
| Protein Name | UMP-CMP kinase |
| Gene Name | CMPK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 26 | QCARIVEKYGYTHLS |
| 43 | ELLRDERKNPDSQYG |
| 55 | QYGELIEKYIKEGKI |
| 86 | TMAANAQKNKFLIDG |
Function
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity
Protein Sequence
10
MKPLVVFVLG
20
GPGAGKGTQC
30
ARIVEKYGYT
40
HLSAGELLRD
50
ERKNPDSQYG
60
ELIEKYIKEG
70
KIVPVEITIS
80
LLKREMDQTM
90
AANAQKNKFL
100
IDGFPRNQDN
110
LQGWNKTMDG
120
KADVSFVLFF
130
DCNNEICIER
140
CLERGKSSGR
150
SDDNRESLEK
160
RIQTYLQSTK
170
PIIDLYEEMG
180
KVKKIDASKS
190
VDEVFDEVVQ
IFDKEG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0036430 | CMP kinase activity |
| Molecular Function | GO:0036431 | dCMP kinase activity |
| Molecular Function | GO:0004550 | nucleoside diphosphate kinase activity |
| Molecular Function | GO:0050145 | nucleoside monophosphate kinase activity |
| Molecular Function | GO:0033862 | UMP kinase activity |
| Molecular Function | GO:0004849 | uridine kinase activity |
| Biological Process | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
| Biological Process | GO:0046705 | CDP biosynthetic process |
| Biological Process | GO:0015949 | nucleobase-containing small molecule interconversion |
| Biological Process | GO:0009220 | pyrimidine ribonucleotide biosynthetic process |
| Biological Process | GO:0006225 | UDP biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.