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Overview

Uniprot IDP30086
Protein NamePhosphatidylethanolamine-binding protein 1
Gene NamePEBP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
113 YVGSGPPKGTGLHRY
132 YEQDRPLKCDEPILS
150 GDHRGKFKVASFRKK
47 VLTPTQVKNRPTSIS
7 *MPVDLSKWSGPLSL

Function

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation

Protein Sequence

10 MPVDLSKWSG 20 PLSLQEVDEQ 30 PQHPLHVTYA 40 GAAVDELGKV 50 LTPTQVKNRP 60 TSISWDGLDS 70 GKLYTLVLTD 80 PDAPSRKDPK 90 YREWHHFLVV 100 NMKGNDISSG 110 TVLSDYVGSG 120 PPKGTGLHRY 130 VWLVYEQDRP 140 LKCDEPILSN 150 RSGDHRGKFK 160 VASFRKKYEL 170 RAPVAGTCYQ 180 AEWDDYVPKL YEQLSGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0008429 phosphatidylethanolamine binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0043409 negative regulation of MAPK cascade

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.