Search Results

Overview

Uniprot IDP30260
Protein NameCell division cycle protein 27 homolog
Gene NameCDC27
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
330 RIGQTGTKSVFSQSG
415 KTKSKTNKGGITQPN
718 SVLFANEKYKSALQE
720 LFANEKYKSALQELE

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861)

Protein Sequence

10 MTVLQEPVQA 20 AIWQALNHYA 30 YRDAVFLAER 40 LYAEVHSEEA 50 LFLLATCYYR 60 SGKAYKAYRL 70 LKGHSCTTPQ 80 CKYLLAKCCV 90 DLSKLAEGEQ 100 ILSGGVFNKQ 110 KSHDDIVTEF 120 GDSACFTLSL 130 LGHVYCKTDR 140 LAKGSECYQK 150 SLSLNPFLWS 160 PFESLCEIGE 170 KPDPDQTFKF 180 TSLQNFSNCL 190 PNSCTTQVPN 200 HSLSHRQPET 210 VLTETPQDTI 220 ELNRLNLESS 230 NSKYSLNTDS 240 SVSYIDSAVI 250 SPDTVPLGTG 260 TSILSKQVQN 270 KPKTGRSLLG 280 GPAALSPLTP 290 SFGILPLETP 300 SPGDGSYLQN 310 YTNTPPVIDV 320 PSTGAPSKKS 330 VARIGQTGTK 340 SVFSQSGNSR 350 EVTPILAQTQ 360 SSGPQTSTTP 370 QVLSPTITSP 380 PNALPRRSSR 390 LFTSDSSTTK 400 ENSKKLKMKF 410 PPKIPNRKTK 420 SKTNKGGITQ 430 PNINDSLEIT 440 KLDSSIISEG 450 KISTITPQIQ 460 AFNLQKAAAE 470 GLMSLLREMG 480 KGYLALCSYN 490 CKEAINILSH 500 LPSHHYNTGW 510 VLCQIGRAYF 520 ELSEYMQAER 530 IFSEVRRIEN 540 YRVEGMEIYS 550 TTLWHLQKDV 560 ALSVLSKDLT 570 DMDKNSPEAW 580 CAAGNCFSLQ 590 REHDIAIKFF 600 QRAIQVDPNY 610 AYAYTLLGHE 620 FVLTEELDKA 630 LACFRNAIRV 640 NPRHYNAWYG 650 LGMIYYKQEK 660 FSLAEMHFQK 670 ALDINPQSSV 680 LLCHIGVVQH 690 ALKKSEKALD 700 TLNKAIVIDP 710 KNPLCKFHRA 720 SVLFANEKYK 730 SALQELEELK 740 QIVPKESLVY 750 FLIGKVYKKL 760 GQTHLALMNF 770 SWAMDLDPKG 780 ANNQIKEAID 790 KRYLPDDEEP 800 ITQEEQIMGT 810 DESQESSMTD 820 ADDTQLHAAE SDEF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005680 anaphase-promoting complex
Biological Process GO:0051301 cell division
Biological Process GO:0007091 metaphase/anaphase transition of mitotic cell cycle
Biological Process GO:0141198 protein branched polyubiquitination
Biological Process GO:0070979 protein K11-linked ubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0051445 regulation of meiotic cell cycle
Biological Process GO:0007346 regulation of mitotic cell cycle
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Molecular Function GO:0140767 enzyme-substrate adaptor activity
Molecular Function GO:0019903 protein phosphatase binding
Biological Process GO:0031145 anaphase-promoting complex-dependent catabolic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.