Search Results
Overview
| Uniprot ID | P30304 |
|---|---|
| Protein Name | M-phase inducer phosphatase 1 |
| Gene Name | CDC25A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | RIHSLPQKLLGCSPA |
Function
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007)
Protein Sequence
10
MELGPEPPHR
20
RRLLFACSPP
30
PASQPVVKAL
40
FGASAAGGLS
50
PVTNLTVTMD
60
QLQGLGSDYE
70
QPLEVKNNSN
80
LQRMGSSEST
90
DSGFCLDSPG
100
PLDSKENLEN
110
PMRRIHSLPQ
120
KLLGCSPALK
130
RSHSDSLDHD
140
IFQLIDPDEN
150
KENEAFEFKK
160
PVRPVSRGCL
170
HSHGLQEGKD
180
LFTQRQNSAP
190
ARMLSSNERD
200
SSEPGNFIPL
210
FTPQSPVTAT
220
LSDEDDGFVD
230
LLDGENLKNE
240
EETPSCMASL
250
WTAPLVMRTT
260
NLDNRCKLFD
270
SPSLCSSSTR
280
SVLKRPERSQ
290
EESPPGSTKR
300
RKSMSGASPK
310
ESTNPEKAHE
320
TLHQSLSLAS
330
SPKGTIENIL
340
DNDPRDLIGD
350
FSKGYLFHTV
360
AGKHQDLKYI
370
SPEIMASVLN
380
GKFANLIKEF
390
VIIDCRYPYE
400
YEGGHIKGAV
410
NLHMEEEVED
420
FLLKKPIVPT
430
DGKRVIVVFH
440
CEFSSERGPR
450
MCRYVRERDR
460
LGNEYPKLHY
470
PELYVLKGGY
480
KEFFMKCQSY
490
CEPPSYRPMH
500
HEDFKEDLKK
510
FRTKSRTWAG
520
EKSKREMYSR
LKKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0045740 | positive regulation of DNA replication |
| Biological Process | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| Biological Process | GO:0110032 | positive regulation of G2/MI transition of meiotic cell cycle |
| Biological Process | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| Biological Process | GO:0009314 | response to radiation |
Reference
PMID: N/A