Search Results
Overview
| Uniprot ID | P30405 |
|---|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
| Gene Name | PPIF |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | NHNGTGGKSIYGSRF |
| 160 | QFFICTIKTDWLDGK |
| 167 | KTDWLDGKHVVFGHV |
| 175 | HVVFGHVKEGMDVVK |
| 183 | EGMDVVKKIESFGSK |
| 190 | KIESFGSKSGRTSKK |
| 57 | LDVDANGKPLGRVVL |
| 67 | GRVVLELKADVVPKT |
| 73 | LKADVVPKTAENFRA |
| 86 | RALCTGEKGFGYKGS |
| 91 | GEKGFGYKGSTFHRV |
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005757 | mitochondrial permeability transition pore complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0016018 | cyclosporin A binding |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0071243 | cellular response to arsenic-containing substance |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:1902686 | mitochondrial outer membrane permeabilization involved in programmed cell death |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:0090324 | negative regulation of oxidative phosphorylation |
| Biological Process | GO:0090201 | negative regulation of release of cytochrome c from mitochondria |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0046902 | regulation of mitochondrial membrane permeability |
| Biological Process | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death |
| Biological Process | GO:0002931 | response to ischemia |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.