Search Results
Overview
| Uniprot ID | P30519 |
|---|---|
| Protein Name | Heme oxygenase 2 |
| Gene Name | HMOX2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 264 | DGKGDMRKCPFYAAE |
Function
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron
Protein Sequence
10
MSAEVETSEG
20
VDESEKKNSG
30
ALEKENQMRM
40
ADLSELLKEG
50
TKEAHDRAEN
60
TQFVKDFLKG
70
NIKKELFKLA
80
TTALYFTYSA
90
LEEEMERNKD
100
HPAFAPLYFP
110
MELHRKEALT
120
KDMEYFFGEN
130
WEEQVQCPKA
140
AQKYVERIHY
150
IGQNEPELLV
160
AHAYTRYMGD
170
LSGGQVLKKV
180
AQRALKLPST
190
GEGTQFYLFE
200
NVDNAQQFKQ
210
LYRARMNALD
220
LNMKTKERIV
230
EEANKAFEYN
240
MQIFNELDQA
250
GSTLARETLE
260
DGFPVHDGKG
270
DMRKCPFYAA
280
EQDKGALEGS
290
SCPFRTAMAV
300
LRKPSLQFIL
310
AAGVALAAGL
LAWYYM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0035579 | specific granule membrane |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0004392 | heme oxygenase (decyclizing) activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0042167 | heme catabolic process |
| Biological Process | GO:0006788 | heme oxidation |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.