Search Results
Overview
| Uniprot ID | P30520 |
|---|---|
| Protein Name | Adenylosuccinate synthetase isozyme 2 |
| Gene Name | ADSS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 125 | KGLEGWEKRLIISDR |
| 157 | QRQEQAGKNLGTTKK |
Function
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Protein Sequence
10
MAFAETYPAA
20
SSLPNGDCGR
30
PRARPGGNRV
40
TVVLGAQWGD
50
EGKGKVVDLL
60
AQDADIVCRC
70
QGGNNAGHTV
80
VVDSVEYDFH
90
LLPSGIINPN
100
VTAFIGNGVV
110
IHLPGLFEEA
120
EKNVQKGKGL
130
EGWEKRLIIS
140
DRAHIVFDFH
150
QAADGIQEQQ
160
RQEQAGKNLG
170
TTKKGIGPVY
180
SSKAARSGLR
190
MCDLVSDFDG
200
FSERFKVLAN
210
QYKSIYPTLE
220
IDIEGELQKL
230
KGYMEKIKPM
240
VRDGVYFLYE
250
ALHGPPKKIL
260
VEGANAALLD
270
IDFGTYPFVT
280
SSNCTVGGVC
290
TGLGMPPQNV
300
GEVYGVVKAY
310
TTRVGIGAFP
320
TEQDNEIGEL
330
LQTRGREFGV
340
TTGRKRRCGW
350
LDLVLLKYAH
360
MINGFTALAL
370
TKLDILDMFT
380
EIKVGVAYKL
390
DGEIIPHIPA
400
NQEVLNKVEV
410
QYKTLPGWNT
420
DISNARAFKE
430
LPVNAQNYVR
440
FIEDELQIPV
450
KWIGVGKSRE
SMIQLF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004019 | adenylosuccinate synthase activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0042301 | phosphate ion binding |
| Biological Process | GO:0044208 | 'de novo' AMP biosynthetic process |
| Biological Process | GO:0006167 | AMP biosynthetic process |
| Biological Process | GO:0006531 | aspartate metabolic process |
| Biological Process | GO:0071257 | cellular response to electrical stimulus |
| Biological Process | GO:0002376 | immune system process |
| Biological Process | GO:0046040 | IMP metabolic process |
| Biological Process | GO:0060359 | response to ammonium ion |
| Biological Process | GO:0014074 | response to purine-containing compound |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.