Search Results

Overview

Uniprot IDP30622
Protein NameCAP-Gly domain-containing linker protein 1
Gene NameCLIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1168 LKQAAAQKSQQLSAL
14 SGLKAPTKILKPGST
24 KPGSTALKTPTAVVA
346 TSSRYARKISGTTAL
35 AVVAPVEKTISSEKA
360 LQEALKEKQQHIEQL
706 LMKVIKEKENSLEAI

Function

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking

Protein Sequence

10 MSMLKPSGLK 20 APTKILKPGS 30 TALKTPTAVV 40 APVEKTISSE 50 KASSTPSSET 60 QEEFVDDFRV 70 GERVWVNGNK 80 PGFIQFLGET 90 QFAPGQWAGI 100 VLDEPIGKND 110 GSVAGVRYFQ 120 CEPLKGIFTR 130 PSKLTRKVQA 140 EDEANGLQTT 150 PASRATSPLC 160 TSTASMVSSS 170 PSTPSNIPQK 180 PSQPAAKEPS 190 ATPPISNLTK 200 TASESISNLS 210 EAGSIKKGER 220 ELKIGDRVLV 230 GGTKAGVVRF 240 LGETDFAKGE 250 WCGVELDEPL 260 GKNDGAVAGT 270 RYFQCQPKYG 280 LFAPVHKVTK 290 IGFPSTTPAK 300 AKANAVRRVM 310 ATTSASLKRS 320 PSASSLSSMS 330 SVASSVSSRP 340 SRTGLLTETS 350 SRYARKISGT 360 TALQEALKEK 370 QQHIEQLLAE 380 RDLERAEVAK 390 ATSHVGEIEQ 400 ELALARDGHD 410 QHVLELEAKM 420 DQLRTMVEAA 430 DREKVELLNQ 440 LEEEKRKVED 450 LQFRVEEESI 460 TKGDLEQKSQ 470 ISEDPENTQT 480 KLEHARIKEL 490 EQSLLFEKTK 500 ADKLQRELED 510 TRVATVSEKS 520 RIMELEKDLA 530 LRVQEVAELR 540 RRLESNKPAG 550 DVDMSLSLLQ 560 EISSLQEKLE 570 VTRTDHQREI 580 TSLKEHFGAR 590 EETHQKEIKA 600 LYTATEKLSK 610 ENESLKSKLE 620 HANKENSDVI 630 ALWKSKLETA 640 IASHQQAMEE 650 LKVSFSKGLG 660 TETAEFAELK 670 TQIEKMRLDY 680 QHEIENLQNQ 690 QDSERAAHAK 700 EMEALRAKLM 710 KVIKEKENSL 720 EAIRSKLDKA 730 EDQHLVEMED 740 TLNKLQEAEI 750 KVKELEVLQA 760 KCNEQTKVID 770 NFTSQLKATE 780 EKLLDLDALR 790 KASSEGKSEM 800 KKLRQQLEAA 810 EKQIKHLEIE 820 KNAESSKASS 830 ITRELQGREL 840 KLTNLQENLS 850 EVSQVKETLE 860 KELQILKEKF 870 AEASEEAVSV 880 QRSMQETVNK 890 LHQKEEQFNM 900 LSSDLEKLRE 910 NLADMEAKFR 920 EKDEREEQLI 930 KAKEKLENDI 940 AEIMKMSGDN 950 SSQLTKMNDE 960 LRLKERDVEE 970 LQLKLTKANE 980 NASFLQKSIE 990 DMTVKAEQSQ 1000 QEAAKKHEEE 1010 KKELERKLSD 1020 LEKKMETSHN 1030 QCQELKARYE 1040 RATSETKTKH 1050 EEILQNLQKT 1060 LLDTEDKLKG 1070 AREENSGLLQ 1080 ELEELRKQAD 1090 KAKAAQTAED 1100 AMQIMEQMTK 1110 EKTETLASLE 1120 DTKQTNAKLQ 1130 NELDTLKENN 1140 LKNVEELNKS 1150 KELLTVENQK 1160 MEEFRKEIET 1170 LKQAAAQKSQ 1180 QLSALQEENV 1190 KLAEELGRSR 1200 DEVTSHQKLE 1210 EERSVLNNQL 1220 LEMKKRESKF 1230 IKDADEEKAS 1240 LQKSISITSA 1250 LLTEKDAELE 1260 KLRNEVTVLR 1270 GENASAKSLH 1280 SVVQTLESDK 1290 VKLELKVKNL 1300 ELQLKENKRQ 1310 LSSSSGNTDT 1320 QADEDERAQE 1330 SQIDFLNSVI 1340 VDLQRKNQDL 1350 KMKVEMMSEA 1360 ALNGNGDDLN 1370 NYDSDDQEKQ 1380 SKKKPRLFCD 1390 ICDCFDLHDT 1400 EDCPTQAQMS 1410 EDPPHSTHHG 1420 SRGEERPYCE 1430 ICEMFGHWAT NCNDDETF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001726 ruffle
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0051010 microtubule plus-end binding
Molecular Function GO:0015631 tubulin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0031122 cytoplasmic microtubule organization
Biological Process GO:0001578 microtubule bundle formation
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0031116 positive regulation of microtubule polymerization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.