Search Results
Overview
| Uniprot ID | P30626 |
|---|---|
| Protein Name | Sorcin |
| Gene Name | SRI |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | QAVNSIAKRYSTNGK |
Function
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels
Protein Sequence
10
MAYPGHPGAG
20
GGYYPGGYGG
30
APGGPAFPGQ
40
TQDPLYGYFA
50
AVAGQDGQID
60
ADELQRCLTQ
70
SGIAGGYKPF
80
NLETCRLMVS
90
MLDRDMSGTM
100
GFNEFKELWA
110
VLNGWRQHFI
120
SFDTDRSGTV
130
DPQELQKALT
140
TMGFRLSPQA
150
VNSIAKRYST
160
NGKITFDDYI
170
ACCVKLRALT
180
DSFRRRDTAQ
190
QGVVNFPYDD
FIQCVMSV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Cellular Component | GO:0030315 | T-tubule |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0140416 | transcription regulator inhibitor activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0055118 | negative regulation of cardiac muscle contraction |
| Biological Process | GO:0010459 | negative regulation of heart rate |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Biological Process | GO:0051924 | regulation of calcium ion transport |
| Biological Process | GO:0086004 | regulation of cardiac muscle cell contraction |
| Biological Process | GO:0010649 | regulation of cell communication by electrical coupling |
| Biological Process | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction |
| Biological Process | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process | GO:1901077 | regulation of relaxation of muscle |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.