Search Results

Overview

Uniprot IDP30837
Protein NameAldehyde dehydrogenase family 1 member B1, mitochondrial
Gene NameALDH1B1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
155 YFAGWADKWHGKTIP
272 EVGHLIQKAAGDSNL
280 AAGDSNLKRVTLELG
347 VEKAKQRKVGNPFEL
379 GYIQLGQKEGAKLLC
383 LGQKEGAKLLCGGER
426 GPVQPLFKFKKIEEV
429 QPLFKFKKIEEVVER
500 ELGEDGLKAYTEVKT
506 LKAYTEVKTVTIKVP
52 WQDAVSKKTFPTVNP

Function

Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes (PubMed:20616185, PubMed:25413692, PubMed:35788181). Shows an absolute preference for NAD(+) as no activity is detected with NADP(+) (PubMed:20616185, PubMed:25413692). Has a high affinity and catalytic efficiency toward aliphatic medium-chain saturated aldehydes relative to short-chain and aromatic aldehydes in vitro (PubMed:20616185). Also capable of metabolizing products of lipid peroxidation, namely 4-hydroxynon-2-enal(4-HNE) and malonaldehyde (MDA) but with lower catalytic efficiency (PubMed:20616185). In vitro, it can also display a nitroglycerin reductase activity (PubMed:25413692). Has also an esterase activity in vitro, but this may be not physiologically relevant in vivo (PubMed:20616185)

Protein Sequence

10 MLRFLAPRLL 20 SLQGRTARYS 30 SAAALPSPIL 40 NPDIPYNQLF 50 INNEWQDAVS 60 KKTFPTVNPT 70 TGEVIGHVAE 80 GDRADVDRAV 90 KAAREAFRLG 100 SPWRRMDASE 110 RGRLLNRLAD 120 LVERDRVYLA 130 SLETLDNGKP 140 FQESYALDLD 150 EVIKVYRYFA 160 GWADKWHGKT 170 IPMDGQHFCF 180 TRHEPVGVCG 190 QIIPWNFPLV 200 MQGWKLAPAL 210 ATGNTVVMKV 220 AEQTPLSALY 230 LASLIKEAGF 240 PPGVVNIITG 250 YGPTAGAAIA 260 QHVDVDKVAF 270 TGSTEVGHLI 280 QKAAGDSNLK 290 RVTLELGGKS 300 PSIVLADADM 310 EHAVEQCHEA 320 LFFNMGQCCC 330 AGSRTFVEES 340 IYNEFLERTV 350 EKAKQRKVGN 360 PFELDTQQGP 370 QVDKEQFERV 380 LGYIQLGQKE 390 GAKLLCGGER 400 FGERGFFIKP 410 TVFGGVQDDM 420 RIAKEEIFGP 430 VQPLFKFKKI 440 EEVVERANNT 450 RYGLAAAVFT 460 RDLDKAMYFT 470 QALQAGTVWV 480 NTYNIVTCHT 490 PFGGFKESGN 500 GRELGEDGLK 510 AYTEVKTVTI KVPQKNS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004029 aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0051287 NAD binding
Biological Process GO:0006081 aldehyde metabolic process
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006068 ethanol catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.