Search Results

Overview

Uniprot IDP30838
Protein NameAldehyde dehydrogenase, dimeric NADP-preferring
Gene NameALDH3A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
194 TGSTGVGKIIMTAAA
202 IIMTAAAKHLTPVTL
221 KSPCYVDKNCDLDVA
269 EKLKKSLKEFYGEDA
302 MGLIEGQKVAYGGTG
360 QFINQREKPLALYMF
372 YMFSSNDKVIKKMIA
417 MGSYHGKKSFETFSH
449 RYPPSPAKMTQH***
9 SKISEAVKRARAAFS

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity)

Protein Sequence

10 MSKISEAVKR 20 ARAAFSSGRT 30 RPLQFRIQQL 40 EALQRLIQEQ 50 EQELVGALAA 60 DLHKNEWNAY 70 YEEVVYVLEE 80 IEYMIQKLPE 90 WAADEPVEKT 100 PQTQQDELYI 110 HSEPLGVVLV 120 IGTWNYPFNL 130 TIQPMVGAIA 140 AGNSVVLKPS 150 ELSENMASLL 160 ATIIPQYLDK 170 DLYPVINGGV 180 PETTELLKER 190 FDHILYTGST 200 GVGKIIMTAA 210 AKHLTPVTLE 220 LGGKSPCYVD 230 KNCDLDVACR 240 RIAWGKFMNS 250 GQTCVAPDYI 260 LCDPSIQNQI 270 VEKLKKSLKE 280 FYGEDAKKSR 290 DYGRIISARH 300 FQRVMGLIEG 310 QKVAYGGTGD 320 AATRYIAPTI 330 LTDVDPQSPV 340 MQEEIFGPVL 350 PIVCVRSLEE 360 AIQFINQREK 370 PLALYMFSSN 380 DKVIKKMIAE 390 TSSGGVAAND 400 VIVHITLHSL 410 PFGGVGNSGM 420 GSYHGKKSFE 430 TFSHRRSCLV 440 RPLMNDEGLK 450 VRYPPSPAKM TQH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0016020 membrane
Molecular Function GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
Molecular Function GO:0008106 alcohol dehydrogenase (NADP+) activity
Molecular Function GO:0004029 aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
Molecular Function GO:0018479 benzaldehyde dehydrogenase (NAD+) activity
Biological Process GO:0006081 aldehyde metabolic process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.