Search Results
Overview
| Uniprot ID | P30904 |
|---|---|
| Protein Name | Macrophage migration inhibitory factor |
| Gene Name | Mif |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 78 | AQNRNYSKLLCGLLS |
Function
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity
Protein Sequence
10
MPMFIVNTNV
20
PRASVPEGFL
30
SELTQQLAQA
40
TGKPAQYIAV
50
HVVPDQLMTF
60
SGTSDPCALC
70
SLHSIGKIGG
80
AQNRNYSKLL
90
CGLLSDRLHI
100
SPDRVYINYY
110
DMNAANVGWN
GSTFA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Molecular Function | GO:0004167 | dopachrome isomerase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0050178 | phenylpyruvate tautomerase activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0002035 | brain renin-angiotensin system |
| Biological Process | GO:0019752 | carboxylic acid metabolic process |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0030330 | DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0042756 | drinking behavior |
| Biological Process | GO:0001942 | hair follicle development |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:2000773 | negative regulation of cellular senescence |
| Biological Process | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process | GO:0010760 | negative regulation of macrophage chemotaxis |
| Biological Process | GO:0002906 | negative regulation of mature B cell apoptotic process |
| Biological Process | GO:0033033 | negative regulation of myeloid cell apoptotic process |
| Biological Process | GO:0051248 | negative regulation of protein metabolic process |
| Biological Process | GO:0002675 | positive regulation of acute inflammatory response |
| Biological Process | GO:0090238 | positive regulation of arachidonate secretion |
| Biological Process | GO:0048680 | positive regulation of axon regeneration |
| Biological Process | GO:0030890 | positive regulation of B cell proliferation |
| Biological Process | GO:0141163 | positive regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000343 | positive regulation of chemokine (C-X-C motif) ligand 2 production |
| Biological Process | GO:0001819 | positive regulation of cytokine production |
| Biological Process | GO:0046326 | positive regulation of D-glucose import across plasma membrane |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0045821 | positive regulation of glycolytic process |
| Biological Process | GO:0050778 | positive regulation of immune response |
| Biological Process | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway |
| Biological Process | GO:0061081 | positive regulation of myeloid leukocyte cytokine production involved in immune response |
| Biological Process | GO:0042327 | positive regulation of phosphorylation |
| Biological Process | GO:0043268 | positive regulation of potassium ion transport |
| Biological Process | GO:0061078 | positive regulation of prostaglandin secretion involved in immune response |
| Biological Process | GO:0014911 | positive regulation of smooth muscle cell migration |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0001516 | prostaglandin biosynthetic process |
| Biological Process | GO:0070207 | protein homotrimerization |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0051384 | response to glucocorticoid |
| Biological Process | GO:0009725 | response to hormone |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0009612 | response to mechanical stimulus |
| Biological Process | GO:0032572 | response to menaquinone |
| Biological Process | GO:0032570 | response to progesterone |
| Biological Process | GO:0033197 | response to vitamin E |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0043588 | skin development |
| Biological Process | GO:0007283 | spermatogenesis |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0042056 | chemoattractant activity |
| Molecular Function | GO:0005125 | cytokine activity |
| Molecular Function | GO:0005126 | cytokine receptor binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.