Search Results
Overview
| Uniprot ID | P31000 |
|---|---|
| Protein Name | Vimentin |
| Gene Name | Vim |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 294 | AEEWYKSKFADLSEA |
| 402 | IEIATYRKLLEGEES |
| 445 | SKRTLLIKTVETRDG |
Function
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)
Protein Sequence
10
MSTRSVSSSS
20
YRRMFGGSGT
30
SSRPSSNRSY
40
VTTSTRTYSL
50
GSALRPSTSR
60
SLYSSSPGGA
70
YVTRSSAVRL
80
RSSMPGVRLL
90
QDSVDFSLAD
100
AINTEFKNTR
110
TNEKVELQEL
120
NDRFANYIDK
130
VRFLEQQNKI
140
LLAELEQLKG
150
QGKSRLGDLY
160
EEEMRELRRQ
170
VDQLTNDKAR
180
VEVERDNLAE
190
DIMRLREKLQ
200
EEMLQREEAE
210
STLQSFRQDV
220
DNASLARLDL
230
ERKVESLQEE
240
IAFLKKLHDE
250
EIQELQAQIQ
260
EQHVQIDVDV
270
SKPDLTAALR
280
DVRQQYESVA
290
AKNLQEAEEW
300
YKSKFADLSE
310
AANRNNDALR
320
QAKQESNEYR
330
RQVQSLTCEV
340
DALKGTNESL
350
ERQMREMEEN
360
FALEAANYQD
370
TIGRLQDEIQ
380
NMKEEMARHL
390
REYQDLLNVK
400
MALDIEIATY
410
RKLLEGEESR
420
ISLPLPNFSS
430
LNLRETNLES
440
LPLVDTHSKR
450
TLLIKTVETR
460
DGQVINETSQ
HHDDLE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0045111 | intermediate filament cytoskeleton |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005777 | peroxisome |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045098 | type III intermediate filament |
| Molecular Function | GO:0003725 | double-stranded RNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:1990254 | keratin filament binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:1990782 | protein tyrosine kinase binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0005212 | structural constituent of eye lens |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0014002 | astrocyte development |
| Biological Process | GO:0060020 | Bergmann glial cell differentiation |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0071225 | cellular response to muramyl dipeptide |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0046697 | decidualization |
| Biological Process | GO:0045444 | fat cell differentiation |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0045103 | intermediate filament-based process |
| Biological Process | GO:0070307 | lens fiber cell development |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0032967 | positive regulation of collagen biosynthetic process |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0060252 | positive regulation of glial cell proliferation |
| Biological Process | GO:0050770 | regulation of axonogenesis |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:1900147 | regulation of Schwann cell migration |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0010269 | response to selenium ion |
| Biological Process | GO:0033280 | response to vitamin D |
| Biological Process | GO:0010043 | response to zinc ion |
| Biological Process | GO:0043403 | skeletal muscle tissue regeneration |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.