Overview
| Uniprot ID | P31001 |
|---|
| Protein Name | Desmin |
|---|
| Gene Name | Des |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 240 |
EEIAFLKKVHEEEIR |
| 298 |
AEEWYKSKVSDLTQA |
| 308 |
DLTQAANKNNDALRQ |
| 377 |
EEEIRHLKDEMARHL |
| 43 |
PRAGFGTKGSSSSMT |
| 448 |
TKKTVMIKTIETRDG |
Function
Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (By similarity). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:25394388). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction (PubMed:27102488). Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (PubMed:35959657). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (PubMed:27733623)
Protein Sequence
10
MSQAYSSSQR
20
VSSYRRTFGG
30
APGFSLGSPL
40
SSPVFPRAGF
50
GTKGSSSSMT
60
SRVYQVSRTS
70
GGAGGLGSLR
80
SSRLGTTRAP
90
SYGAGELLDF
100
SLADAVNQEF
110
LATRTNEKVE
120
LQELNDRFAN
130
YIEKVRFLEQ
140
QNAALAAEVN
150
RLKGREPTRV
160
AELYEEEMRE
170
LRRQVEVLTN
180
QRARVDVERD
190
NLIDDLQRLK
200
AKLQEEIQLR
210
EEAENNLAAF
220
RADVDAATLA
230
RIDLERRIES
240
LNEEIAFLKK
250
VHEEEIRELQ
260
AQLQEQQVQV
270
EMDMSKPDLT
280
AALRDIRAQY
290
ETIAAKNISE
300
AEEWYKSKVS
310
DLTQAANKNN
320
DALRQAKQEM
330
MEYRHQIQSY
340
TCEIDALKGT
350
NDSLMRQMRE
360
LEDRFASEAN
370
GYQDNIARLE
380
EEIRHLKDEM
390
ARHLREYQDL
400
LNVKMALDVE
410
IATYRKLLEG
420
EESRINLPIQ
430
TFSALNFRET
440
SPEQRGSEVH
450
TKKTVMIKTI
460
ETRDGEVVSE
ATQQQHEVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097512 |
cardiac myofibril |
| Cellular Component |
GO:0051286 |
cell tip |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0043292 |
contractile muscle fiber |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005916 |
fascia adherens |
| Cellular Component |
GO:0005921 |
gap junction |
| Cellular Component |
GO:0014704 |
intercalated disc |
| Cellular Component |
GO:0045111 |
intermediate filament cytoskeleton |
| Cellular Component |
GO:0031594 |
neuromuscular junction |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Cellular Component |
GO:0045098 |
type III intermediate filament |
| Cellular Component |
GO:0030018 |
Z disc |
| Molecular Function |
GO:0008092 |
cytoskeletal protein binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0045109 |
intermediate filament organization |
| Biological Process |
GO:0007517 |
muscle organ development |
| Biological Process |
GO:0006998 |
nuclear envelope organization |
| Biological Process |
GO:0060538 |
skeletal muscle organ development |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.