Search Results
Overview
| Uniprot ID | P31016 |
|---|---|
| Protein Name | Disks large homolog 4 |
| Gene Name | Dlg4 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 505 | EWSRLKAKDWGSSSG |
| 544 | IIILGPTKDRANDDL |
| 591 | SSREKMEKDIQAHKF |
| 663 | ENVLEINKRITEEQA |
Function
Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15317815, PubMed:15358863, PubMed:19596852, PubMed:20628354, PubMed:23300088, PubMed:26679993). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:19596852). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity)
Protein Sequence
10
MDCLCIVTTK
20
KYRYQDEDTP
30
PLEHSPAHLP
40
NQANSPPVIV
50
NTDTLEAPGY
60
ELQVNGTEGE
70
MEYEEITLER
80
GNSGLGFSIA
90
GGTDNPHIGD
100
DPSIFITKII
110
PGGAAAQDGR
120
LRVNDSILFV
130
NEVDVREVTH
140
SAAVEALKEA
150
GSIVRLYVMR
160
RKPPAEKVME
170
IKLIKGPKGL
180
GFSIAGGVGN
190
QHIPGDNSIY
200
VTKIIEGGAA
210
HKDGRLQIGD
220
KILAVNSVGL
230
EDVMHEDAVA
240
ALKNTYDVVY
250
LKVAKPSNAY
260
LSDSYAPPDI
270
TTSYSQHLDN
280
EISHSSYLGT
290
DYPTAMTPTS
300
PRRYSPVAKD
310
LLGEEDIPRE
320
PRRIVIHRGS
330
TGLGFNIVGG
340
EDGEGIFISF
350
ILAGGPADLS
360
GELRKGDQIL
370
SVNGVDLRNA
380
SHEQAAIALK
390
NAGQTVTIIA
400
QYKPEEYSRF
410
EAKIHDLREQ
420
LMNSSLGSGT
430
ASLRSNPKRG
440
FYIRALFDYD
450
KTKDCGFLSQ
460
ALSFRFGDVL
470
HVIDAGDEEW
480
WQARRVHSDS
490
ETDDIGFIPS
500
KRRVERREWS
510
RLKAKDWGSS
520
SGSQGREDSV
530
LSYETVTQME
540
VHYARPIIIL
550
GPTKDRANDD
560
LLSEFPDKFG
570
SCVPHTTRPK
580
REYEIDGRDY
590
HFVSSREKME
600
KDIQAHKFIE
610
AGQYNSHLYG
620
TSVQSVREVA
630
EQGKHCILDV
640
SANAVRRLQA
650
AHLHPIAIFI
660
RPRSLENVLE
670
INKRITEEQA
680
RKAFDRATKL
690
EQEFTECFSA
700
IVEGDSFEEI
710
YHKVKRVIED
720
LSGPYIWVPA
RERL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032281 | AMPA glutamate receptor complex |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0044300 | cerebellar mossy fiber |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0044307 | dendritic branch |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0044224 | juxtaparanode region of axon |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0044309 | neuron spine |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:1990635 | proximal dendrite |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0097060 | synaptic membrane |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0033130 | acetylcholine receptor binding |
| Molecular Function | GO:0031697 | beta-1 adrenergic receptor binding |
| Molecular Function | GO:0031698 | beta-2 adrenergic receptor binding |
| Molecular Function | GO:0031748 | D1 dopamine receptor binding |
| Molecular Function | GO:0005109 | frizzled binding |
| Molecular Function | GO:0035254 | glutamate receptor binding |
| Molecular Function | GO:0035255 | ionotropic glutamate receptor binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0019894 | kinesin binding |
| Molecular Function | GO:0097109 | neuroligin family protein binding |
| Molecular Function | GO:0031812 | P2Y1 nucleotide receptor binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0098919 | structural constituent of postsynaptic density |
| Biological Process | GO:0097113 | AMPA glutamate receptor clustering |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0035865 | cellular response to potassium ion |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0060997 | dendritic spine morphogenesis |
| Biological Process | GO:0097061 | dendritic spine organization |
| Biological Process | GO:0045184 | establishment of protein localization |
| Biological Process | GO:0035641 | locomotory exploration behavior |
| Biological Process | GO:0002091 | negative regulation of receptor internalization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0050885 | neuromuscular process controlling balance |
| Biological Process | GO:0045161 | neuronal ion channel clustering |
| Biological Process | GO:0099645 | neurotransmitter receptor localization to postsynaptic specialization membrane |
| Biological Process | GO:0098989 | NMDA selective glutamate receptor signaling pathway |
| Biological Process | GO:1904719 | positive regulation of AMPA glutamate receptor clustering |
| Biological Process | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0050775 | positive regulation of dendrite morphogenesis |
| Biological Process | GO:2000463 | positive regulation of excitatory postsynaptic potential |
| Biological Process | GO:0150012 | positive regulation of neuron projection arborization |
| Biological Process | GO:0051965 | positive regulation of synapse assembly |
| Biological Process | GO:0050806 | positive regulation of synaptic transmission |
| Biological Process | GO:0035418 | protein localization to synapse |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0097120 | receptor localization to synapse |
| Biological Process | GO:2000821 | regulation of grooming behavior |
| Biological Process | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:0048168 | regulation of neuronal synaptic plasticity |
| Biological Process | GO:2000310 | regulation of NMDA receptor activity |
| Biological Process | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| Biological Process | GO:0035176 | social behavior |
| Biological Process | GO:0016188 | synaptic vesicle maturation |
| Biological Process | GO:0071625 | vocalization behavior |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.