Search Results

Overview

Uniprot IDP31040
Protein NameSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gene NameSDHA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
167 FSRTEDGKIYQRAFG
179 AFGGQSLKFGKGGQA
182 GQSLKFGKGGQAHRC
250 SIHRIRAKNTVVATG
335 ERYAPVAKDLASRDV
361 GRGCGPEKDHVYLQL
480 ESCRPGDKVPPIKPN
485 GDKVPPIKPNAGEES
517 ELRLSMQKSMQNHAA
538 VLQEGCGKISKLYGD
541 EGCGKISKLYGDLKH
547 SKLYGDLKHLKTFDR
550 YGDLKHLKTFDRGMV
608 IDEYDYSKPIQGQQK
615 KPIQGQQKKPFEEHW
624 PFEEHWRKHTLSYVD

Function

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10746566, PubMed:24781757). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (PubMed:20484225)

Protein Sequence

10 MSGVRGLSRL 20 LSARRLALAK 30 AWPTVLQTGT 40 RGFHFTVDGN 50 KRASAKVSDS 60 ISAQYPVVDH 70 EFDAVVVGAG 80 GAGLRAAFGL 90 SEAGFNTACV 100 TKLFPTRSHT 110 VAAQGGINAA 120 LGNMEEDNWR 130 WHFYDTVKGS 140 DWLGDQDAIH 150 YMTEQAPAAV 160 VELENYGMPF 170 SRTEDGKIYQ 180 RAFGGQSLKF 190 GKGGQAHRCC 200 CVADRTGHSL 210 LHTLYGRSLR 220 YDTSYFVEYF 230 ALDLLMENGE 240 CRGVIALCIE 250 DGSIHRIRAK 260 NTVVATGGYG 270 RTYFSCTSAH 280 TSTGDGTAMI 290 TRAGLPCQDL 300 EFVQFHPTGI 310 YGAGCLITEG 320 CRGEGGILIN 330 SQGERFMERY 340 APVAKDLASR 350 DVVSRSMTLE 360 IREGRGCGPE 370 KDHVYLQLHH 380 LPPEQLATRL 390 PGISETAMIF 400 AGVDVTKEPI 410 PVLPTVHYNM 420 GGIPTNYKGQ 430 VLRHVNGQDQ 440 IVPGLYACGE 450 AACASVHGAN 460 RLGANSLLDL 470 VVFGRACALS 480 IEESCRPGDK 490 VPPIKPNAGE 500 ESVMNLDKLR 510 FADGSIRTSE 520 LRLSMQKSMQ 530 NHAAVFRVGS 540 VLQEGCGKIS 550 KLYGDLKHLK 560 TFDRGMVWNT 570 DLVETLELQN 580 LMLCALQTIY 590 GAEARKESRG 600 AHAREDYKVR 610 IDEYDYSKPI 620 QGQQKKPFEE 630 HWRKHTLSYV 640 DVGTGKVTLE 650 YRPVIDKTLN 660 EADCATVPPA IRSY

Gene Ontology

Classification GO ID Description
Molecular Function GO:0009055 electron transfer activity
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045273 respiratory chain complex II (succinate dehydrogenase)
Molecular Function GO:0071949 FAD binding
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0008177 succinate dehydrogenase (quinone) activity
Biological Process GO:0006121 mitochondrial electron transport, succinate to ubiquinone
Biological Process GO:0007399 nervous system development
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Biological Process GO:0022904 respiratory electron transport chain
Biological Process GO:0006105 succinate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.