Search Results
Overview
| Uniprot ID | P31044 |
|---|---|
| Protein Name | Phosphatidylethanolamine-binding protein 1 |
| Gene Name | Pebp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | YVGSGPPKDTGLHRY |
| 150 | GDNRGKFKVESFRKK |
| 157 | KVESFRKKYHLGAPV |
Function
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity)
Protein Sequence
10
MAADISQWAG
20
PLSLQEVDEP
30
PQHALRVDYG
40
GVTVDELGKV
50
LTPTQVMNRP
60
SSISWDGLDP
70
GKLYTLVLTD
80
PDAPSRKDPK
90
FREWHHFLVV
100
NMKGNDISSG
110
TVLSEYVGSG
120
PPKDTGLHRY
130
VWLVYEQEQP
140
LNCDEPILSN
150
KSGDNRGKFK
160
VESFRKKYHL
170
GAPVAGTCFQ
180
AEWDDSVPKL
HDQLAGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045177 | apical part of cell |
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0051019 | mitogen-activated protein kinase binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0033612 | receptor serine/threonine kinase binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0042755 | eating behavior |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0001933 | negative regulation of protein phosphorylation |
| Biological Process | GO:1905923 | positive regulation of acetylcholine biosynthetic process |
| Biological Process | GO:0060409 | positive regulation of acetylcholine metabolic process |
| Biological Process | GO:0141163 | positive regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0045840 | positive regulation of mitotic nuclear division |
| Biological Process | GO:0002026 | regulation of the force of heart contraction |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0051591 | response to cAMP |
| Biological Process | GO:0051412 | response to corticosterone |
| Biological Process | GO:0051602 | response to electrical stimulus |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0048240 | sperm capacitation |
| Biological Process | GO:0007286 | spermatid development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.