Search Results

Overview

Uniprot IDP31146
Protein NameCoronin-1A
Gene NameCORO1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 VTLEGHTKRVGIVAW
207 VRIIEPRKGTVVAEK
324 RGMGYMPKRGLEVNK
355 IAMTVPRKSDLFQED

Function

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes

Protein Sequence

10 MSRQVVRSSK 20 FRHVFGQPAK 30 ADQCYEDVRV 40 SQTTWDSGFC 50 AVNPKFVALI 60 CEASGGGAFL 70 VLPLGKTGRV 80 DKNAPTVCGH 90 TAPVLDIAWC 100 PHNDNVIASG 110 SEDCTVMVWE 120 IPDGGLMLPL 130 REPVVTLEGH 140 TKRVGIVAWH 150 TTAQNVLLSA 160 GCDNVIMVWD 170 VGTGAAMLTL 180 GPEVHPDTIY 190 SVDWSRDGGL 200 ICTSCRDKRV 210 RIIEPRKGTV 220 VAEKDRPHEG 230 TRPVRAVFVS 240 EGKILTTGFS 250 RMSERQVALW 260 DTKHLEEPLS 270 LQELDTSSGV 280 LLPFFDPDTN 290 IVYLCGKGDS 300 SIRYFEITSE 310 APFLHYLSMF 320 SSKESQRGMG 330 YMPKRGLEVN 340 KCEIARFYKL 350 HERRCEPIAM 360 TVPRKSDLFQ 370 EDLYPPTAGP 380 DPALTAEEWL 390 GGRDAGPLLI 400 SLKDGYVPPK 410 SRELRVNRGL 420 DTGRRRAAPE 430 ASGTPSSDAV 440 SRLEEEMRKL 450 QATVQELQKR 460 LDRLEETVQA K

Gene Ontology

Classification GO ID Description
Molecular Function GO:0051015 actin filament binding
Cellular Component GO:0005884 actin filament
Cellular Component GO:0030424 axon
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0001772 immunological synapse
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0016020 membrane
Cellular Component GO:0001891 phagocytic cup
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0030670 phagocytic vesicle membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003779 actin binding
Molecular Function GO:0003785 actin monomer binding
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0032036 myosin heavy chain binding
Molecular Function GO:0043548 phosphatidylinositol 3-kinase binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0007015 actin filament organization
Biological Process GO:0016477 cell migration
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0045087 innate immune response
Biological Process GO:0043320 natural killer cell degranulation
Biological Process GO:0051126 negative regulation of actin nucleation
Biological Process GO:0006909 phagocytosis
Biological Process GO:0001845 phagolysosome assembly
Biological Process GO:0050918 positive chemotaxis
Biological Process GO:0032956 regulation of actin cytoskeleton organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.