Search Results
Overview
| Uniprot ID | P31153 |
|---|---|
| Protein Name | S-adenosylmethionine synthase isoform type-2 |
| Gene Name | MAT2A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 228 | ALKEKVIKAVVPAKY |
Function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate
Protein Sequence
10
MNGQLNGFHE
20
AFIEEGTFLF
30
TSESVGEGHP
40
DKICDQISDA
50
VLDAHLQQDP
60
DAKVACETVA
70
KTGMILLAGE
80
ITSRAAVDYQ
90
KVVREAVKHI
100
GYDDSSKGFD
110
YKTCNVLVAL
120
EQQSPDIAQG
130
VHLDRNEEDI
140
GAGDQGLMFG
150
YATDETEECM
160
PLTIVLAHKL
170
NAKLAELRRN
180
GTLPWLRPDS
190
KTQVTVQYMQ
200
DRGAVLPIRV
210
HTIVISVQHD
220
EEVCLDEMRD
230
ALKEKVIKAV
240
VPAKYLDEDT
250
IYHLQPSGRF
260
VIGGPQGDAG
270
LTGRKIIVDT
280
YGGWGAHGGG
290
AFSGKDYTKV
300
DRSAAYAARW
310
VAKSLVKGGL
320
CRRVLVQVSY
330
AIGVSHPLSI
340
SIFHYGTSQK
350
SERELLEIVK
360
KNFDLRPGVI
370
VRDLDLKKPI
380
YQRTAAYGHF
390
GRDSFPWEVP
KKLKY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0048269 | methionine adenosyltransferase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004478 | methionine adenosyltransferase activity |
| Molecular Function | GO:0036094 | small molecule binding |
| Biological Process | GO:0061431 | cellular response to methionine |
| Biological Process | GO:0006730 | one-carbon metabolic process |
| Biological Process | GO:1904263 | positive regulation of TORC1 signaling |
| Biological Process | GO:0051291 | protein heterooligomerization |
| Biological Process | GO:0034214 | protein hexamerization |
| Biological Process | GO:0006556 | S-adenosylmethionine biosynthetic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.