Overview
| Uniprot ID | P31213 |
|---|
| Protein Name | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
|---|
| Gene Name | SRD5A2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 41 |
GKHTESLKPAATRLP |
Function
Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed:10898110, PubMed:23685396). Converts testosterone into 5-alpha-dihydrotestosterone (DHT), the most active androgen in the prostate, as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development (PubMed:10898110, PubMed:23685396). Besides testosterone, it can also act on other steroids, including progesterone, producing metabolites with diverse roles (PubMed:10898110). Hence, it plays a central role in sexual differentiation and androgen physiology (PubMed:10898110)
Protein Sequence
10
MQVQCQQSPV
20
LAGSATLVAL
30
GALALYVAKP
40
SGYGKHTESL
50
KPAATRLPAR
60
AAWFLQELPS
70
FAVPAGILAR
80
QPLSLFGPPG
90
TVLLGLFCLH
100
YFHRTFVYSL
110
LNRGRPYPAI
120
LILRGTAFCT
130
GNGVLQGYYL
140
IYCAEYPDGW
150
YTDIRFSLGV
160
FLFILGMGIN
170
IHSDYILRQL
180
RKPGEISYRI
190
PQGGLFTYVS
200
GANFLGEIIE
210
WIGYALATWS
220
LPALAFAFFS
230
LCFLGLRAFH
240
HHRFYLKMFE
250
DYPKSRKALI
PFIF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070852 |
cell body fiber |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Molecular Function |
GO:0047751 |
3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0003865 |
3-oxo-5-alpha-steroid 4-dehydrogenase activity |
| Molecular Function |
GO:0033218 |
amide binding |
| Molecular Function |
GO:0047045 |
testosterone dehydrogenase (NADP+) activity |
| Biological Process |
GO:0006702 |
androgen biosynthetic process |
| Biological Process |
GO:0008209 |
androgen metabolic process |
| Biological Process |
GO:0060348 |
bone development |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0007267 |
cell-cell signaling |
| Biological Process |
GO:0018894 |
dibenzo-p-dioxin metabolic process |
| Biological Process |
GO:0030540 |
female genitalia development |
| Biological Process |
GO:0021766 |
hippocampus development |
| Biological Process |
GO:0021854 |
hypothalamus development |
| Biological Process |
GO:0030539 |
male genitalia development |
| Biological Process |
GO:0008584 |
male gonad development |
| Biological Process |
GO:0018963 |
phthalate metabolic process |
| Biological Process |
GO:1904614 |
response to biphenyl |
| Biological Process |
GO:0032354 |
response to follicle-stimulating hormone |
| Biological Process |
GO:0031667 |
response to nutrient levels |
| Biological Process |
GO:0043434 |
response to peptide hormone |
| Biological Process |
GO:0048545 |
response to steroid hormone |
| Biological Process |
GO:0033574 |
response to testosterone |
| Biological Process |
GO:0009410 |
response to xenobiotic stimulus |
| Biological Process |
GO:0006706 |
steroid catabolic process |
| Biological Process |
GO:0061370 |
testosterone biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.