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Overview

Uniprot IDP31270
Protein NameHomeobox protein Hox-A11
Gene NameHOXA11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
72 YAIEPATKWHPRGNL

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Protein Sequence

10 MDFDERGPCS 20 SNMYLPSCTY 30 YVSGPDFSSL 40 PSFLPQTPSS 50 RPMTYSYSSN 60 LPQVQPVREV 70 TFREYAIEPA 80 TKWHPRGNLA 90 HCYSAEELVH 100 RDCLQAPSAA 110 GVPGDVLAKS 120 SANVYHHPTP 130 AVSSNFYSTV 140 GRNGVLPQAF 150 DQFFETAYGT 160 PENLASSDYP 170 GDKSAEKGPP 180 AATATSAAAA 190 AAATGAPATS 200 SSDSGGGGGC 210 RETAAAAEEK 220 ERRRRPESSS 230 SPESSSGHTE 240 DKAGGSSGQR 250 TRKKRCPYTK 260 YQIRELEREF 270 FFSVYINKEK 280 RLQLSRMLNL 290 TDRQVKIWFQ 300 NRRMKEKKIN 310 RDRLQYYSAN PLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0032993 protein-DNA complex
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0001658 branching involved in ureteric bud morphogenesis
Biological Process GO:0060351 cartilage development involved in endochondral bone morphogenesis
Biological Process GO:0048589 developmental growth
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0009953 dorsal/ventral pattern formation
Biological Process GO:0030326 embryonic limb morphogenesis
Biological Process GO:0060272 embryonic skeletal joint morphogenesis
Biological Process GO:0007501 mesodermal cell fate specification
Biological Process GO:0010720 positive regulation of cell development
Biological Process GO:0032332 positive regulation of chondrocyte differentiation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0030850 prostate gland development
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0043627 response to estrogen
Biological Process GO:0033574 response to testosterone
Biological Process GO:0001501 skeletal system development

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.