Search Results
Overview
| Uniprot ID | P31321 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type I-beta regulatory subunit |
| Gene Name | PRKAR1B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 367 | GPCSEILKRNIQRYN |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells
Protein Sequence
10
MASPPACPSE
20
EDESLKGCEL
30
YVQLHGIQQV
40
LKDCIVHLCI
50
SKPERPMKFL
60
REHFEKLEKE
70
ENRQILARQK
80
SNSQSDSHDE
90
EVSPTPPNPV
100
VKARRRRGGV
110
SAEVYTEEDA
120
VSYVRKVIPK
130
DYKTMTALAK
140
AISKNVLFAH
150
LDDNERSDIF
160
DAMFPVTHIA
170
GETVIQQGNE
180
GDNFYVVDQG
190
EVDVYVNGEW
200
VTNISEGGSF
210
GELALIYGTP
220
RAATVKAKTD
230
LKLWGIDRDS
240
YRRILMGSTL
250
RKRKMYEEFL
260
SKVSILESLE
270
KWERLTVADA
280
LEPVQFEDGE
290
KIVVQGEPGD
300
DFYIITEGTA
310
SVLQRRSPNE
320
EYVEVGRLGP
330
SDYFGEIALL
340
LNRPRAATVV
350
ARGPLKCVKL
360
DRPRFERVLG
370
PCSEILKRNI
380
QRYNSFISLT
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0097546 | ciliary base |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Biological Process | GO:0034199 | activation of protein kinase A activity |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0071377 | cellular response to glucagon stimulus |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
| Biological Process | GO:2000463 | positive regulation of excitatory postsynaptic potential |
| Biological Process | GO:1903367 | positive regulation of fear response |
| Biological Process | GO:1900273 | positive regulation of long-term synaptic potentiation |
| Biological Process | GO:0098693 | regulation of synaptic vesicle cycle |
| Biological Process | GO:0003091 | renal water homeostasis |
| Biological Process | GO:0097700 | vascular endothelial cell response to laminar fluid shear stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.