Search Results
Overview
| Uniprot ID | P31323 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type II-beta regulatory subunit |
| Gene Name | PRKAR2B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 287 | LEFSERLKVVDVIGT |
| 393 | GPCMEIMKRNIATYE |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
Protein Sequence
10
MSIEIPAGLT
20
ELLQGFTVEV
30
LRHQPADLLE
40
FALQHFTRLQ
50
QENERKGTAR
60
FGHEGRTWGD
70
LGAAAGGGTP
80
SKGVNFAEEP
90
MQSDSEDGEE
100
EEAAPADAGA
110
FNAPVINRFT
120
RRASVCAEAY
130
NPDEEEDDAE
140
SRIIHPKTDD
150
QRNRLQEACK
160
DILLFKNLDP
170
EQMSQVLDAM
180
FEKLVKDGEH
190
VIDQGDDGDN
200
FYVIDRGTFD
210
IYVKCDGVGR
220
CVGNYDNRGS
230
FGELALMYNT
240
PRAATITATS
250
PGALWGLDRV
260
TFRRIIVKNN
270
AKKRKMYESF
280
IESLPFLKSL
290
EFSERLKVVD
300
VIGTKVYNDG
310
EQIIAQGDSA
320
DSFFIVESGE
330
VKITMKRKGK
340
SEVEENGAVE
350
IARCSRGQYF
360
GELALVTNKP
370
RAASAHAIGT
380
VKCLAMDVQA
390
FERLLGPCME
400
IMKRNIATYE
410
EQLVALFGTN
MDIVEPTA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0097546 | ciliary base |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0034199 | activation of protein kinase A activity |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0071377 | cellular response to glucagon stimulus |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
| Biological Process | GO:0003091 | renal water homeostasis |
| Biological Process | GO:0097332 | response to antipsychotic drug |
| Biological Process | GO:0097700 | vascular endothelial cell response to laminar fluid shear stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.