Search Results
Overview
| Uniprot ID | P31325 |
|---|---|
| Protein Name | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform |
| Gene Name | Phkg2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | EKVALSEKETRSIMR |
Function
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM
Protein Sequence
10
MTLDVGPEDE
20
LPDWAAAKEF
30
YQKYDPKDII
40
GRGVSSVVRR
50
CVHRATGDEF
60
AVKIMEVSAE
70
RLSLEQLEEV
80
RDATRREMHI
90
LRQVAGHPHI
100
ITLIDSYESS
110
SFMFLVFDLM
120
RKGELFDYLT
130
EKVALSEKET
140
RSIMRSLLEA
150
VNFLHVNNIV
160
HRDLKPENIL
170
LDDNMQIRLS
180
DFGFSCHLEP
190
GEKLRELCGT
200
PGYLAPEILK
210
CSMDETHPGY
220
GKEVDLWACG
230
VILFTLLAGS
240
PPFWHRRQIL
250
MLRMIMEGQY
260
QFSSPEWDDR
270
SNTVKDLIAK
280
LLQVDPNARL
290
TAEQALQHPF
300
FERCKGSQPW
310
NLTPRQRFRV
320
AVWTILAAGR
330
VALSSHRLRP
340
LTKNALLRDP
350
YALRPVRRLI
360
DNCAFRLYGH
370
WVKKGEQQNR
380
AALFQHQPPR
390
PFPIIATDLE
400
GDSSAITEDE
VTLVRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005964 | phosphorylase kinase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004689 | phosphorylase kinase activity |
| Biological Process | GO:0005980 | glycogen catabolic process |
| Biological Process | GO:0005977 | glycogen metabolic process |
| Biological Process | GO:0045819 | positive regulation of glycogen catabolic process |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.