Search Results
Overview
| Uniprot ID | P31327 |
|---|---|
| Protein Name | Carbamoyl-phosphate synthase [ammonia], mitochondrial |
| Gene Name | CPS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1009 | TLRQLGKKTVVVNCN |
| 1074 | PLYKNGVKIMGTSPL |
| 1100 | SAVLDELKVAQAPWK |
| 1107 | KVAQAPWKAVNTLNE |
| 1150 | FSEDEMKKFLEEATR |
| 1168 | EHPVVLTKFVEGARE |
| 1183 | VEMDAVGKDGRVISH |
| 1222 | ISQGAIEKVKDATRK |
| 1269 | RSFPFVSKTLGVDFI |
| 1291 | IGENVDEKHLPTLDH |
| 1356 | AMLSTGFKIPQKGIL |
| 1360 | TGFKIPQKGILIGIQ |
| 138 | LLVLDYSKDYNHWLA |
| 1471 | LTNFQVTKLFAEAVQ |
| 1479 | LFAEAVQKSRKVDSK |
| 1486 | KSRKVDSKSLFHYRQ |
| 171 | VDTRMLTKIIRDKGT |
| 176 | LTKIIRDKGTMLGKI |
| 197 | VDFVDPNKQNLIAEV |
| 207 | LIAEVSTKDVKVYGK |
| 210 | EVSTKDVKVYGKGNP |
| 214 | KDVKVYGKGNPTKVV |
| 219 | YGKGNPTKVVAVDCG |
| 228 | VAVDCGIKNNVIRLL |
| 280 | PLIQNVRKILESDRK |
| 287 | KILESDRKEPLFGIS |
| 307 | TGLAAGAKTYKMSMA |
| 310 | AAGAKTYKMSMANRG |
| 400 | SFFSLIKKGKATTIT |
| 402 | FSLIKKGKATTITSV |
| 412 | TITSVLPKPALVASR |
| 453 | SQAVKAMKEENVKTV |
| 527 | LFKRGVLKEYGVKVL |
| 532 | VLKEYGVKVLGTSVE |
| 55 | IVLEDGTKMKGYSFG |
| 553 | DRQLFSDKLNEINEK |
| 560 | KLNEINEKIAPSFAV |
| 57 | LEDGTKMKGYSFGHP |
| 624 | TNQILVEKSVTGWKE |
| 630 | EKSVTGWKEIEYEVV |
| 751 | GIPLPEIKNVVSGKT |
| 757 | IKNVVSGKTSACFEP |
| 772 | SLDYMVTKIPRWDLD |
| 793 | SRIGSSMKSVGEVMA |
| 811 | TFEESFQKALRMCHP |
| 831 | TPRLPMNKEWPSNLD |
| 841 | PSNLDLRKELSEPSS |
| 856 | TRIYAIAKAIDDNMS |
| 869 | MSLDEIEKLTYIDKW |
| 875 | EKLTYIDKWFLYKMR |
| 880 | IDKWFLYKMRDILNM |
| 889 | RDILNMEKTLKGLNS |
| 892 | LNMEKTLKGLNSESM |
| 905 | SMTEETLKRAKEIGF |
| 908 | EETLKRAKEIGFSDK |
| 915 | KEIGFSDKQISKCLG |
| 919 | FSDKQISKCLGLTEA |
| 935 | TRELRLKKNIHPWVK |
Function
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell
Protein Sequence
10
MTRILTAFKV
20
VRTLKTGFGF
30
TNVTAHQKWK
40
FSRPGIRLLS
50
VKAQTAHIVL
60
EDGTKMKGYS
70
FGHPSSVAGE
80
VVFNTGLGGY
90
PEAITDPAYK
100
GQILTMANPI
110
IGNGGAPDTT
120
ALDELGLSKY
130
LESNGIKVSG
140
LLVLDYSKDY
150
NHWLATKSLG
160
QWLQEEKVPA
170
IYGVDTRMLT
180
KIIRDKGTML
190
GKIEFEGQPV
200
DFVDPNKQNL
210
IAEVSTKDVK
220
VYGKGNPTKV
230
VAVDCGIKNN
240
VIRLLVKRGA
250
EVHLVPWNHD
260
FTKMEYDGIL
270
IAGGPGNPAL
280
AEPLIQNVRK
290
ILESDRKEPL
300
FGISTGNLIT
310
GLAAGAKTYK
320
MSMANRGQNQ
330
PVLNITNKQA
340
FITAQNHGYA
350
LDNTLPAGWK
360
PLFVNVNDQT
370
NEGIMHESKP
380
FFAVQFHPEV
390
TPGPIDTEYL
400
FDSFFSLIKK
410
GKATTITSVL
420
PKPALVASRV
430
EVSKVLILGS
440
GGLSIGQAGE
450
FDYSGSQAVK
460
AMKEENVKTV
470
LMNPNIASVQ
480
TNEVGLKQAD
490
TVYFLPITPQ
500
FVTEVIKAEQ
510
PDGLILGMGG
520
QTALNCGVEL
530
FKRGVLKEYG
540
VKVLGTSVES
550
IMATEDRQLF
560
SDKLNEINEK
570
IAPSFAVESI
580
EDALKAADTI
590
GYPVMIRSAY
600
ALGGLGSGIC
610
PNRETLMDLS
620
TKAFAMTNQI
630
LVEKSVTGWK
640
EIEYEVVRDA
650
DDNCVTVCNM
660
ENVDAMGVHT
670
GDSVVVAPAQ
680
TLSNAEFQML
690
RRTSINVVRH
700
LGIVGECNIQ
710
FALHPTSMEY
720
CIIEVNARLS
730
RSSALASKAT
740
GYPLAFIAAK
750
IALGIPLPEI
760
KNVVSGKTSA
770
CFEPSLDYMV
780
TKIPRWDLDR
790
FHGTSSRIGS
800
SMKSVGEVMA
810
IGRTFEESFQ
820
KALRMCHPSI
830
EGFTPRLPMN
840
KEWPSNLDLR
850
KELSEPSSTR
860
IYAIAKAIDD
870
NMSLDEIEKL
880
TYIDKWFLYK
890
MRDILNMEKT
900
LKGLNSESMT
910
EETLKRAKEI
920
GFSDKQISKC
930
LGLTEAQTRE
940
LRLKKNIHPW
950
VKQIDTLAAE
960
YPSVTNYLYV
970
TYNGQEHDVN
980
FDDHGMMVLG
990
CGPYHIGSSV
1000
EFDWCAVSSI
1010
RTLRQLGKKT
1020
VVVNCNPETV
1030
STDFDECDKL
1040
YFEELSLERI
1050
LDIYHQEACG
1060
GCIISVGGQI
1070
PNNLAVPLYK
1080
NGVKIMGTSP
1090
LQIDRAEDRS
1100
IFSAVLDELK
1110
VAQAPWKAVN
1120
TLNEALEFAK
1130
SVDYPCLLRP
1140
SYVLSGSAMN
1150
VVFSEDEMKK
1160
FLEEATRVSQ
1170
EHPVVLTKFV
1180
EGAREVEMDA
1190
VGKDGRVISH
1200
AISEHVEDAG
1210
VHSGDATLML
1220
PTQTISQGAI
1230
EKVKDATRKI
1240
AKAFAISGPF
1250
NVQFLVKGND
1260
VLVIECNLRA
1270
SRSFPFVSKT
1280
LGVDFIDVAT
1290
KVMIGENVDE
1300
KHLPTLDHPI
1310
IPADYVAIKA
1320
PMFSWPRLRD
1330
ADPILRCEMA
1340
STGEVACFGE
1350
GIHTAFLKAM
1360
LSTGFKIPQK
1370
GILIGIQQSF
1380
RPRFLGVAEQ
1390
LHNEGFKLFA
1400
TEATSDWLNA
1410
NNVPATPVAW
1420
PSQEGQNPSL
1430
SSIRKLIRDG
1440
SIDLVINLPN
1450
NNTKFVHDNY
1460
VIRRTAVDSG
1470
IPLLTNFQVT
1480
KLFAEAVQKS
1490
RKVDSKSLFH
1500
YRQYSAGKAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004087 | carbamoyl-phosphate synthase (ammonia) activity |
| Molecular Function | GO:0004088 | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| Molecular Function | GO:0004175 | endopeptidase activity |
| Molecular Function | GO:0016595 | glutamate binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0072341 | modified amino acid binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0030955 | potassium ion binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0036094 | small molecule binding |
| Biological Process | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
| Biological Process | GO:0070409 | carbamoyl phosphate biosynthetic process |
| Biological Process | GO:0071242 | cellular response to ammonium ion |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0071377 | cellular response to glucagon stimulus |
| Biological Process | GO:0071400 | cellular response to oleic acid |
| Biological Process | GO:0019240 | citrulline biosynthetic process |
| Biological Process | GO:0006541 | glutamine metabolic process |
| Biological Process | GO:0070365 | hepatocyte differentiation |
| Biological Process | GO:0050667 | homocysteine metabolic process |
| Biological Process | GO:0007494 | midgut development |
| Biological Process | GO:0055081 | monoatomic anion homeostasis |
| Biological Process | GO:0046209 | nitric oxide metabolic process |
| Biological Process | GO:0097305 | response to alcohol |
| Biological Process | GO:0014075 | response to amine |
| Biological Process | GO:0043200 | response to amino acid |
| Biological Process | GO:0071548 | response to dexamethasone |
| Biological Process | GO:0032094 | response to food |
| Biological Process | GO:0060416 | response to growth hormone |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0042594 | response to starvation |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0010043 | response to zinc ion |
| Biological Process | GO:0019433 | triglyceride catabolic process |
| Biological Process | GO:0000050 | urea cycle |
| Biological Process | GO:0042311 | vasodilation |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.