Search Results
Overview
| Uniprot ID | P31350 |
|---|---|
| Protein Name | Ribonucleoside-diphosphate reductase subunit M2 |
| Gene Name | RRM2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 206 | TMPCVKKKADWALRW |
| 46 | GTRVLASKTARRIFQ |
Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling
Protein Sequence
10
MLSLRVPLAP
20
ITDPQQLQLS
30
PLKGLSLVDK
40
ENTPPALSGT
50
RVLASKTARR
60
IFQEPTEPKT
70
KAAAPGVEDE
80
PLLRENPRRF
90
VIFPIEYHDI
100
WQMYKKAEAS
110
FWTAEEVDLS
120
KDIQHWESLK
130
PEERYFISHV
140
LAFFAASDGI
150
VNENLVERFS
160
QEVQITEARC
170
FYGFQIAMEN
180
IHSEMYSLLI
190
DTYIKDPKER
200
EFLFNAIETM
210
PCVKKKADWA
220
LRWIGDKEAT
230
YGERVVAFAA
240
VEGIFFSGSF
250
ASIFWLKKRG
260
LMPGLTFSNE
270
LISRDEGLHC
280
DFACLMFKHL
290
VHKPSEERVR
300
EIIINAVRIE
310
QEFLTEALPV
320
KLIGMNCTLM
330
KQYIEFVADR
340
LMLELGFSKV
350
FRVENPFDFM
360
ENISLEGKTN
370
FFEKRVGEYQ
380
RMGVMSSPTE
NSFTLDADF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005971 | ribonucleoside-diphosphate reductase complex |
| Molecular Function | GO:0008199 | ferric iron binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0036175 | ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor |
| Molecular Function | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| Biological Process | GO:0009265 | 2'-deoxyribonucleotide biosynthetic process |
| Biological Process | GO:0009263 | deoxyribonucleotide biosynthetic process |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0051290 | protein heterotetramerization |
| Biological Process | GO:0009185 | ribonucleoside diphosphate metabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.