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Overview

Uniprot IDP31399
Protein NameATP synthase peripheral stalk subunit d, mitochondrial
Gene NameAtp5pd
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
117 ARVREYEKQLEKIKN
149 ETKLDKRKYPYWPHQ
63 YYRANVDKPGLVDDF
71 PGLVDDFKNKYNALK
73 LVDDFKNKYNALKIP
78 KNKYNALKIPVPEDK
85 KIPVPEDKYTALVDA
95 ALVDAEEKEDVKNCA
99 AEEKEDVKNCAQFVT

Function

Subunit d, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)

Protein Sequence

10 MAGRKLALKT 20 IDWVSFVEIM 30 PQNQKAIGNA 40 LKSWNETFHT 50 RLASLSEKPP 60 AIDWAYYRAN 70 VDKPGLVDDF 80 KNKYNALKIP 90 VPEDKYTALV 100 DAEEKEDVKN 110 CAQFVTGSQA 120 RVREYEKQLE 130 KIKNMIPFDQ 140 MTIDDLNEVF 150 PETKLDKRKY 160 PYWPHQPIEN L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0015078 proton transmembrane transporter activity
Biological Process GO:1901653 cellular response to peptide
Biological Process GO:0015986 proton motive force-driven ATP synthesis
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.