Search Results
Overview
| Uniprot ID | P31512 |
|---|---|
| Protein Name | Dimethylaniline monooxygenase [N-oxide-forming] 4 |
| Gene Name | FMO4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | FPGIHKFKGQILHSQ |
Function
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides
Protein Sequence
10
MAKKVAVIGA
20
GVSGLSSIKC
30
CVDEDLEPTC
40
FERSDDIGGL
50
WKFTESSKDG
60
MTRVYKSLVT
70
NVCKEMSCYS
80
DFPFHEDYPN
90
FMNHEKFWDY
100
LQEFAEHFDL
110
LKYIQFKTTV
120
CSITKRPDFS
130
ETGQWDVVTE
140
TEGKQNRAVF
150
DAVMVCTGHF
160
LNPHLPLEAF
170
PGIHKFKGQI
180
LHSQEYKIPE
190
GFQGKRVLVI
200
GLGNTGGDIA
210
VELSRTAAQV
220
LLSTRTGTWV
230
LGRSSDWGYP
240
YNMMVTRRCC
250
SFIAQVLPSR
260
FLNWIQERKL
270
NKRFNHEDYG
280
LSITKGKKAK
290
FIVNDELPNC
300
ILCGAITMKT
310
SVIEFTETSA
320
VFEDGTVEEN
330
IDVVIFTTGY
340
TFSFPFFEEP
350
LKSLCTKKIF
360
LYKQVFPLNL
370
ERATLAIIGL
380
IGLKGSILSG
390
TELQARWVTR
400
VFKGLCKIPP
410
SQKLMMEATE
420
KEQLIKRGVF
430
KDTSKDKFDY
440
IAYMDDIAAC
450
IGTKPSIPLL
460
FLKDPRLAWE
470
VFFGPCTPYQ
480
YRLMGPGKWD
490
GARNAILTQW
500
DRTLKPLKTR
510
IVPDSSKPAS
520
MSHYLKAWGA
530
PVLLASLLLI
540
CKSSLFLKLV
550
RDKLQDRMSP
YLVSLWRG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0004499 | N,N-dimethylaniline monooxygenase activity |
| Molecular Function | GO:0050661 | NADP binding |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.