Search Results

Overview

Uniprot IDP31513
Protein NameFlavin-containing monooxygenase 3
Gene NameFMO3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 AKEKNLLKYIQFKTF
107 LLKYIQFKTFVSSVN
115 TFVSSVNKHPDFATT
157 HVYPNLPKESFPGLN
167 FPGLNHFKGKCFHSR
169 GLNHFKGKCFHSRDY
185 EPGVFNGKRVLVVGL
265 KQMNARFKHENYGLM
4 ****MGKKVAIIGAG
42 NDIGGLWKFSDHAEE
56 EGRASIYKSVFSNSS
96 EYIIAFAKEKNLLKY

Function

Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269)

Protein Sequence

10 MGKKVAIIGA 20 GVSGLASIRS 30 CLEEGLEPTC 40 FEKSNDIGGL 50 WKFSDHAEEG 60 RASIYKSVFS 70 NSSKEMMCFP 80 DFPFPDDFPN 90 FMHNSKIQEY 100 IIAFAKEKNL 110 LKYIQFKTFV 120 SSVNKHPDFA 130 TTGQWDVTTE 140 RDGKKESAVF 150 DAVMVCSGHH 160 VYPNLPKESF 170 PGLNHFKGKC 180 FHSRDYKEPG 190 VFNGKRVLVV 200 GLGNSGCDIA 210 TELSRTAEQV 220 MISSRSGSWV 230 MSRVWDNGYP 240 WDMLLVTRFG 250 TFLKNNLPTA 260 ISDWLYVKQM 270 NARFKHENYG 280 LMPLNGVLRK 290 EPVFNDELPA 300 SILCGIVSVK 310 PNVKEFTETS 320 AIFEDGTIFE 330 GIDCVIFATG 340 YSFAYPFLDE 350 SIIKSRNNEI 360 ILFKGVFPPL 370 LEKSTIAVIG 380 FVQSLGAAIP 390 TVDLQSRWAA 400 QVIKGTCTLP 410 SMEDMMNDIN 420 EKMEKKRKWF 430 GKSETIQTDY 440 IVYMDELSSF 450 IGAKPNIPWL 460 FLTDPKLAME 470 VYFGPCSPYQ 480 FRLVGPGQWP 490 GARNAILTQW 500 DRSLKPMQTR 510 VVGRLQKPCF 520 FFHWLKLFAI 530 PILLIAVFLV LT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Molecular Function GO:0047638 albendazole monooxygenase activity
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0047822 hypotaurine monooxygenase activity
Molecular Function GO:0004499 N,N-dimethylaniline monooxygenase activity
Molecular Function GO:0050661 NADP binding
Molecular Function GO:0034899 trimethylamine monooxygenase activity
Biological Process GO:0042412 taurine biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.