Search Results

Overview

Uniprot IDP31596
Protein NameExcitatory amino acid transporter 2
Gene NameSlc1a2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
12 EGANNMPKQVEVRMH
151 PGNPKLKKQLGPGKK
157 KKQLGPGKKNDEVSS
193 QQIQTVTKKVLVAPP
29 HLSSEEPKHRNLGMR
382 EDNLGIDKRVTRFVL
526 QSVYDDTKNHRESNS
570 SVEEEPWKREK****

Function

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1448170, PubMed:7913472). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:1448170). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity)

Protein Sequence

10 MASTEGANNM 20 PKQVEVRMHD 30 SHLSSEEPKH 40 RNLGMRMCDK 50 LGKNLLLSLT 60 VFGVILGAVC 70 GGLLRLAAPI 80 HPDVVMLIAF 90 PGDILMRMLK 100 MLILPLIISS 110 LITGLSGLDA 120 KASGRLGTRA 130 MVYYMSTTII 140 AAVLGVILVL 150 AIHPGNPKLK 160 KQLGPGKKND 170 EVSSLDAFLD 180 LIRNLFPENL 190 VQACFQQIQT 200 VTKKVLVAPP 210 SEEANTTKAV 220 ISLLNETMNE 230 APEETKIVIK 240 KGLEFKDGMN 250 VLGLIGFFIA 260 FGIAMGKMGE 270 QAKLMVEFFN 280 ILNEIVMKLV 290 IMIMWYSPLG 300 IACLICGKII 310 AIKDLEVVAR 320 QLGMYMITVI 330 VGLIIHGGIF 340 LPLIYFVVTR 350 KNPFSFFAGI 360 FQAWITALGT 370 ASSAGTLPVT 380 FRCLEDNLGI 390 DKRVTRFVLP 400 VGATINMDGT 410 ALYEAVAAIF 420 IAQMNGVILD 430 GGQIVTVSLT 440 ATLASIGAAS 450 IPSAGLVTML 460 LILTAVGLPT 470 EDISLLVAVD 480 WLLDRMRTSV 490 NVVGDSFGAG 500 IVYHLSKSEL 510 DTIDSQHRMH 520 EDIEMTKTQS 530 VYDDTKNHRE 540 SNSNQCVYAA 550 HNSVVIDECK 560 VTLAANGKSA 570 DCSVEEEPWK REK

Gene Ontology

Classification GO ID Description
Biological Process GO:0007632 visual behavior
Cellular Component GO:0097449 astrocyte projection
Cellular Component GO:0030673 axolemma
Cellular Component GO:0030424 axon
Cellular Component GO:0044297 cell body
Cellular Component GO:0009986 cell surface
Cellular Component GO:0043198 dendritic shaft
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0098796 membrane protein complex
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0044306 neuron projection terminus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0045202 synapse
Cellular Component GO:0031982 vesicle
Molecular Function GO:0033229 cysteine transmembrane transporter activity
Molecular Function GO:0015501 glutamate:sodium symporter activity
Molecular Function GO:0005314 high-affinity L-glutamate transmembrane transporter activity
Molecular Function GO:0005313 L-glutamate transmembrane transporter activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0008509 monoatomic anion transmembrane transporter activity
Molecular Function GO:0015175 neutral L-amino acid transmembrane transporter activity
Biological Process GO:0030534 adult behavior
Biological Process GO:0071314 cellular response to cocaine
Biological Process GO:0070779 D-aspartate import across plasma membrane
Biological Process GO:0006750 glutathione biosynthetic process
Biological Process GO:0140009 L-aspartate import across plasma membrane
Biological Process GO:0070778 L-aspartate transmembrane transport
Biological Process GO:0098712 L-glutamate import across plasma membrane
Biological Process GO:0015813 L-glutamate transmembrane transport
Biological Process GO:0098656 monoatomic anion transmembrane transport
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0007399 nervous system development
Biological Process GO:0098810 neurotransmitter reuptake
Biological Process GO:0006836 neurotransmitter transport
Biological Process GO:0046326 positive regulation of D-glucose import across plasma membrane
Biological Process GO:0070207 protein homotrimerization
Biological Process GO:0043200 response to amino acid
Biological Process GO:0046677 response to antibiotic
Biological Process GO:0045471 response to ethanol
Biological Process GO:0009416 response to light stimulus
Biological Process GO:0009611 response to wounding
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0021537 telencephalon development

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.