Overview
| Uniprot ID | P31641 |
|---|
| Protein Name | Sodium- and chloride-dependent taurine transporter |
|---|
| Gene Name | SLC6A6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 6 |
**MATKEKLQCLKDF |
Function
Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:31345061, PubMed:31903486, PubMed:39837997, PubMed:40108165, PubMed:40108449, PubMed:40615403, PubMed:40789850, PubMed:41269860, PubMed:41652173, PubMed:8010975, PubMed:8382624, PubMed:8654117). Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). In addition to mediate extracellular taurine uptake, also able to mediate transport of taurine into mitochondria, sustaining mitochondrial translation (PubMed:41652173). Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:39837997, PubMed:40108165, PubMed:40789850, PubMed:41269860, PubMed:8010975)
Protein Sequence
10
MATKEKLQCL
20
KDFHKDILKP
30
SPGKSPGTRP
40
EDEAEGKPPQ
50
REKWSSKIDF
60
VLSVAGGFVG
70
LGNVWRFPYL
80
CYKNGGGAFL
90
IPYFIFLFGS
100
GLPVFFLEII
110
IGQYTSEGGI
120
TCWEKICPLF
130
SGIGYASVVI
140
VSLLNVYYIV
150
ILAWATYYLF
160
QSFQKELPWA
170
HCNHSWNTPH
180
CMEDTMRKNK
190
SVWITISSTN
200
FTSPVIEFWE
210
RNVLSLSPGI
220
DHPGSLKWDL
230
ALCLLLVWLV
240
CFFCIWKGVR
250
STGKVVYFTA
260
TFPFAMLLVL
270
LVRGLTLPGA
280
GAGIKFYLYP
290
DITRLEDPQV
300
WIDAGTQIFF
310
SYAICLGAMT
320
SLGSYNKYKY
330
NSYRDCMLLG
340
CLNSGTSFVS
350
GFAIFSILGF
360
MAQEQGVDIA
370
DVAESGPGLA
380
FIAYPKAVTM
390
MPLPTFWSIL
400
FFIMLLLLGL
410
DSQFVEVEGQ
420
ITSLVDLYPS
430
FLRKGYRREI
440
FIAFVCSISY
450
LLGLTMVTEG
460
GMYVFQLFDY
470
YAASGVCLLW
480
VAFFECFVIA
490
WIYGGDNLYD
500
GIEDMIGYRP
510
GPWMKYSWAV
520
ITPVLCVGCF
530
IFSLVKYVPL
540
TYNKTYVYPN
550
WAIGLGWSLA
560
LSSMLCVPLV
570
IVIRLCQTEG
580
PFLVRVKYLL
590
TPREPNRWAV
600
EREGATPYNS
610
RTVMNGALVK
620
PTHIIVETMM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0042995 |
cell projection |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0098982 |
GABA-ergic synapse |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0031528 |
microvillus membrane |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045211 |
postsynaptic membrane |
| Molecular Function |
GO:0022858 |
alanine transmembrane transporter activity |
| Molecular Function |
GO:0015171 |
amino acid transmembrane transporter activity |
| Molecular Function |
GO:0005283 |
amino acid:sodium symporter activity |
| Molecular Function |
GO:0015185 |
gamma-aminobutyric acid transmembrane transporter activity |
| Molecular Function |
GO:0005332 |
gamma-aminobutyric acid:sodium:chloride symporter activity |
| Molecular Function |
GO:0005368 |
taurine transmembrane transporter activity |
| Molecular Function |
GO:0005369 |
taurine:sodium symporter activity |
| Biological Process |
GO:0032328 |
alanine transport |
| Biological Process |
GO:0089718 |
amino acid import across plasma membrane |
| Biological Process |
GO:0006865 |
amino acid transport |
| Biological Process |
GO:0051939 |
gamma-aminobutyric acid import |
| Biological Process |
GO:0098739 |
import across plasma membrane |
| Biological Process |
GO:0050804 |
modulation of chemical synaptic transmission |
| Biological Process |
GO:0006836 |
neurotransmitter transport |
| Biological Process |
GO:0045597 |
positive regulation of cell differentiation |
| Biological Process |
GO:0035725 |
sodium ion transmembrane transport |
| Biological Process |
GO:0015734 |
taurine transmembrane transport |
| Biological Process |
GO:0150104 |
transport across blood-brain barrier |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.