Search Results
Overview
| Uniprot ID | P31647 |
|---|---|
| Protein Name | Sodium- and chloride-dependent GABA transporter 3 |
| Gene Name | Slc6a11 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 40 | GTREARDKAVHERGH |
| 578 | TEGTLPEKLQKLTVP |
| 581 | TLPEKLQKLTVPSAD |
| 612 | NDCEAKVKGDGTISA |
| 623 | TISAITEKETHF*** |
Function
Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:1400419, PubMed:1497897). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity)
Protein Sequence
10
MTAEQALPLG
20
NGKAAEEARG
30
SEALGGGGGG
40
AAGTREARDK
50
AVHERGHWNN
60
KVEFVLSVAG
70
EIIGLGNVWR
80
FPYLCYKNGG
90
GAFLIPYVVF
100
FICCGIPVFF
110
LETALGQFTS
120
EGGITCWRRV
130
CPLFEGIGYA
140
TQVIEAHLNV
150
YYIIILAWAI
160
FYLSNCFTTE
170
LPWATCGHEW
180
NTEKCVEFQK
190
LNFSNYSHVS
200
LQNATSPVME
210
FWERRVLAIS
220
DGIEHIGNLR
230
WELALCLLAA
240
WTICYFCIWK
250
GTKSTGKVVY
260
VTATFPYIML
270
LILLIRGVTL
280
PGASEGIKFY
290
LYPDLSRLSD
300
PQVWVDAGTQ
310
IFFSYAICLG
320
CLTALGSYNN
330
YNNNCYRDCI
340
MLCCLNSGTS
350
FVAGFAIFSV
360
LGFMAYEQGV
370
PIAEVAESGP
380
GLAFIAYPKA
390
VTMMPLSPLW
400
ATLFFMMLIF
410
LGLDSQFVCV
420
ESLVTAVVDM
430
YPKVFRRGYR
440
RELLILALSI
450
VSYFLGLVML
460
TEGGMYIFQL
470
FDSYAASGMC
480
LLFVAIFECV
490
CIGWVYGSNR
500
FYDNIEDMIG
510
YRPLSLIKWC
520
WKVVTPGICA
530
GIFIFFLVKY
540
KPLKYNNVYT
550
YPAWGYGIGW
560
LMALSSMLCI
570
PLWIFIKLWK
580
TEGTLPEKLQ
590
KLTVPSADLK
600
MRGKLGASPR
610
MVTVNDCEAK
620
VKGDGTISAI
TEKETHF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042995 | cell projection |
| Biological Process | GO:0001504 | neurotransmitter uptake |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0016597 | amino acid binding |
| Molecular Function | GO:0005283 | amino acid:sodium symporter activity |
| Molecular Function | GO:0005332 | gamma-aminobutyric acid:sodium:chloride symporter activity |
| Molecular Function | GO:0008028 | monocarboxylic acid transmembrane transporter activity |
| Molecular Function | GO:0005369 | taurine:sodium symporter activity |
| Biological Process | GO:0006865 | amino acid transport |
| Biological Process | GO:0015718 | monocarboxylic acid transport |
| Biological Process | GO:0006836 | neurotransmitter transport |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.