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Overview

Uniprot IDP31686
Protein Name4-coumarate--CoA ligase 1
Gene Name-
OrganismGlycine max

Kla Sites from experimental identification

Position Flanking peptide
253 EIKQFISKQVVFYKR

Function

Carboxylate--CoA ligase that may use 4-coumarate as substrate. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester

Protein Sequence

10 AKATILLMPK 20 FDINSLLALI 30 HKHKVTIAPV 40 VPPIVLAISK 50 SPDLHKYDLS 60 SIRVLKSGGA 70 PLGKELEDTL 80 RAKFPNAKLG 90 QGYGMTEAGP 100 VLTMSLAFAK 110 EPIDVKPGAC 120 GTVVRNAEMK 130 IVDPETGHSL 140 PRNQSGEICI 150 RGDQIMKGYL 160 NDGEATERTI 170 DKDGWLHTGD 180 IGYIDDDDEL 190 FIVDRLKELI 200 KYKGFQVAPA 210 ELEALLLTHP 220 KISDAAVVPM 230 KDEAAGEVPV 240 AFVVISNGYT 250 DTTEDEIKQF 260 ISKQVVFYKR 270 INRVFFIDAI 280 PKSPSGKILR 290 KDLRAKIAAS VPK

Gene Ontology

Classification GO ID Description
Molecular Function GO:0016207 4-coumarate-CoA ligase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016405 CoA-ligase activity
Biological Process GO:0009698 phenylpropanoid metabolic process

Reference

[1] Xu C, Li J, Dong C, Zhang Y, Li H et al.. Lactylome Profiling Reveals the Potential Role of Lysine Lactylation in Regulating Soybean Seed Quality.. J Agric Food Chem 73(23):14666-14676. 2025 Jun 11. PMID: 40440508.