Search Results
Overview
| Uniprot ID | P31786 |
|---|---|
| Protein Name | Acyl-CoA-binding protein |
| Gene Name | Dbi |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 55 | LDLKGKAKWDSWNKL |
| 77 | AMKTYVEKVDELKKK |
| 8 | MSQAEFDKAAEEVKR |
Function
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor
Protein Sequence
10
MSQAEFDKAA
20
EEVKRLKTQP
30
TDEEMLFIYS
40
HFKQATVGDV
50
NTDRPGLLDL
60
KGKAKWDSWN
70
KLKGTSKESA
80
MKTYVEKVDE
LKKKYGI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0097038 | perinuclear endoplasmic reticulum |
| Cellular Component | GO:0032994 | protein-lipid complex |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0030156 | benzodiazepine receptor binding |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036042 | long-chain fatty acyl-CoA binding |
| Biological Process | GO:0001662 | behavioral fear response |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0001942 | hair follicle development |
| Biological Process | GO:0021670 | lateral ventricle development |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0036151 | phosphatidylcholine acyl-chain remodeling |
| Biological Process | GO:2001140 | positive regulation of phospholipid transport |
| Biological Process | GO:0032228 | regulation of synaptic transmission, GABAergic |
| Biological Process | GO:0043588 | skin development |
| Biological Process | GO:0006641 | triglyceride metabolic process |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.