Search Results

Overview

Uniprot ID	P31930
Protein Name	Cytochrome b-c1 complex subunit 1, mitochondrial
Gene Name	UQCRC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
102	HLAFKGTKNRPGSAL
134	EHTAYYIKALSKDLP
138	YYIKALSKDLPKAVE
225	EYLSTHYKAPRMVLA
85	GSRFETEKNNGAGYF

Function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179)

Protein Sequence

10 MAASVVCRAA 20 TAGAQVLLRA 30 RRSPALLRTP 40 ALRSTATFAQ 50 ALQFVPETQV 60 SLLDNGLRVA 70 SEQSSQPTCT 80 VGVWIDVGSR 90 FETEKNNGAG 100 YFLEHLAFKG 110 TKNRPGSALE 120 KEVESMGAHL 130 NAYSTREHTA 140 YYIKALSKDL 150 PKAVELLGDI 160 VQNCSLEDSQ 170 IEKERDVILR 180 EMQENDASMR 190 DVVFNYLHAT 200 AFQGTPLAQA 210 VEGPSENVRK 220 LSRADLTEYL 230 STHYKAPRMV 240 LAAAGGVEHQ 250 QLLDLAQKHL 260 GGIPWTYAED 270 AVPTLTPCRF 280 TGSEIRHRDD 290 ALPFAHVAIA 300 VEGPGWASPD 310 NVALQVANAI 320 IGHYDCTYGG 330 GVHLSSPLAS 340 GAVANKLCQS 350 FQTFSICYAE 360 TGLLGAHFVC 370 DRMKIDDMMF 380 VLQGQWMRLC 390 TSATESEVAR 400 GKNILRNALV 410 SHLDGTTPVC 420 EDIGRSLLTY 430 GRRIPLAEWE 440 SRIAEVDASV 450 VREICSKYIY 460 DQCPAVAGYG 470 PIEQLPDYNR 480 IRSGMFWLRF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0017087	mitochondrial processing peptidase complex
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0098803	respiratory chain complex
Cellular Component	GO:0045275	respiratory chain complex III
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0008121	quinol-cytochrome-c reductase activity
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0045333	cellular respiration
Biological Process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c
Biological Process	GO:0006119	oxidative phosphorylation
Biological Process	GO:0006627	protein processing involved in protein targeting to mitochondrion
Biological Process	GO:0014823	response to activity
Biological Process	GO:0043279	response to alkaloid

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.