Search Results

Overview

Uniprot ID	P31942
Protein Name	Heterogeneous nuclear ribonucleoprotein H3
Gene Name	HNRNPH3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
6	**MDWVMKHNGPNDA
76	IAENALGKHKERIGH
97	RSSRSEIKGFYDPPR

Function

Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction

Protein Sequence

10 MDWVMKHNGP 20 NDASDGTVRL 30 RGLPFGCSKE 40 EIVQFFQGLE 50 IVPNGITLTM 60 DYQGRSTGEA 70 FVQFASKEIA 80 ENALGKHKER 90 IGHRYIEIFR 100 SSRSEIKGFY 110 DPPRRLLGQR 120 PGPYDRPIGG 130 RGGYYGAGRG 140 SMYDRMRRGG 150 DGYDGGYGGF 160 DDYGGYNNYG 170 YGNDGFDDRM 180 RDGRGMGGHG 190 YGGAGDASSG 200 FHGGHFVHMR 210 GLPFRATEND 220 IANFFSPLNP 230 IRVHIDIGAD 240 GRATGEADVE 250 FVTHEDAVAA 260 MSKDKNNMQH 270 RYIELFLNST 280 PGGGSGMGGS 290 GMGGYGRDGM 300 DNQGGYGSVG 310 RMGMGNNYSG 320 GYGTPDGLGG 330 YGRGGGGSGG 340 YYGQGGMSGG GWRGMY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:1990904	ribonucleoprotein complex
Cellular Component	GO:0005681	spliceosomal complex
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0030855	epithelial cell differentiation
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0043484	regulation of RNA splicing
Biological Process	GO:0006396	RNA processing
Biological Process	GO:0008380	RNA splicing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.