Search Results
Overview
| Uniprot ID | P31947 |
|---|---|
| Protein Name | 14-3-3 protein sigma |
| Gene Name | SFN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | ASLIQKAKLAEQAER |
| 124 | RVFYLKMKGDYYRYL |
| 140 | EVATGDDKKRIIDSA |
| 141 | VATGDDKKRIIDSAR |
| 159 | QEAMDISKKEMPPTN |
| 160 | EAMDISKKEMPPTNP |
| 32 | FMKGAVEKGEELSCE |
| 49 | NLLSVAYKNVVGGQR |
| 77 | NEEGSEEKGPEVREY |
| 9 | ERASLIQKAKLAEQA |
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0050815 | phosphoserine residue binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0008426 | protein kinase C inhibitor activity |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Biological Process | GO:0141156 | cAMP/PKA signal transduction |
| Biological Process | GO:0061436 | establishment of skin barrier |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| Biological Process | GO:0045824 | negative regulation of innate immune response |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:1903077 | negative regulation of protein localization to plasma membrane |
| Biological Process | GO:0045785 | positive regulation of cell adhesion |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0045606 | positive regulation of epidermal cell differentiation |
| Biological Process | GO:0046827 | positive regulation of protein export from nucleus |
| Biological Process | GO:1903829 | positive regulation of protein localization |
| Biological Process | GO:0006611 | protein export from nucleus |
| Biological Process | GO:0022407 | regulation of cell-cell adhesion |
| Biological Process | GO:0010482 | regulation of epidermal cell division |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0001836 | release of cytochrome c from mitochondria |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.