Search Results
Overview
| Uniprot ID | P31994 |
|---|---|
| Protein Name | Low affinity immunoglobulin gamma Fc region receptor II-b |
| Gene Name | FCGR2B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 170 | VTFFQNGKSKKFSRS |
Function
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis
Protein Sequence
10
MGILSFLPVL
20
ATESDWADCK
30
SPQPWGHMLL
40
WTAVLFLAPV
50
AGTPAAPPKA
60
VLKLEPQWIN
70
VLQEDSVTLT
80
CRGTHSPESD
90
SIQWFHNGNL
100
IPTHTQPSYR
110
FKANNNDSGE
120
YTCQTGQTSL
130
SDPVHLTVLS
140
EWLVLQTPHL
150
EFQEGETIVL
160
RCHSWKDKPL
170
VKVTFFQNGK
180
SKKFSRSDPN
190
FSIPQANHSH
200
SGDYHCTGNI
210
GYTLYSSKPV
220
TITVQAPSSS
230
PMGIIVAVVT
240
GIAVAAIVAA
250
VVALIYCRKK
260
RISALPGYPE
270
CREMGETLPE
280
KPANPTNPDE
290
ADKVGAENTI
300
TYSLLMHPDA
310
LEEPDDQNRI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:1902950 | regulation of dendritic spine maintenance |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0019864 | IgG binding |
| Molecular Function | GO:0019770 | IgG receptor activity |
| Molecular Function | GO:0019772 | low-affinity IgG receptor activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0001788 | antibody-dependent cellular cytotoxicity |
| Biological Process | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0006952 | defense response |
| Biological Process | GO:0038094 | Fc-gamma receptor signaling pathway |
| Biological Process | GO:0002316 | follicular B cell differentiation |
| Biological Process | GO:0002266 | follicular dendritic cell activation |
| Biological Process | GO:0002436 | immune complex clearance by monocytes and macrophages |
| Biological Process | GO:0002252 | immune effector process |
| Biological Process | GO:0016064 | immunoglobulin mediated immune response |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0002313 | mature B cell differentiation involved in immune response |
| Biological Process | GO:0002865 | negative regulation of acute inflammatory response to antigenic stimulus |
| Biological Process | GO:0001814 | negative regulation of antibody-dependent cellular cytotoxicity |
| Biological Process | GO:0050869 | negative regulation of B cell activation |
| Biological Process | GO:0030889 | negative regulation of B cell proliferation |
| Biological Process | GO:0050859 | negative regulation of B cell receptor signaling pathway |
| Biological Process | GO:0001818 | negative regulation of cytokine production |
| Biological Process | GO:0043318 | negative regulation of cytotoxic T cell degranulation |
| Biological Process | GO:0002605 | negative regulation of dendritic cell antigen processing and presentation |
| Biological Process | GO:2001199 | negative regulation of dendritic cell differentiation |
| Biological Process | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin |
| Biological Process | GO:0050777 | negative regulation of immune response |
| Biological Process | GO:0002638 | negative regulation of immunoglobulin production |
| Biological Process | GO:0032693 | negative regulation of interleukin-10 production |
| Biological Process | GO:0043031 | negative regulation of macrophage activation |
| Biological Process | GO:1902564 | negative regulation of neutrophil activation |
| Biological Process | GO:0050765 | negative regulation of phagocytosis |
| Biological Process | GO:0001811 | negative regulation of type I hypersensitivity |
| Biological Process | GO:0006909 | phagocytosis |
| Biological Process | GO:0002922 | positive regulation of humoral immune response |
| Biological Process | GO:0046330 | positive regulation of JNK cascade |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:1905898 | positive regulation of response to endoplasmic reticulum stress |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
| Biological Process | GO:0002819 | regulation of adaptive immune response |
| Biological Process | GO:0002622 | regulation of B cell antigen processing and presentation |
| Biological Process | GO:1903381 | regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway |
| Biological Process | GO:0090264 | regulation of immune complex clearance by monocytes and macrophages |
| Biological Process | GO:0045088 | regulation of innate immune response |
| Biological Process | GO:0009617 | response to bacterium |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.