Search Results
Overview
| Uniprot ID | P32004 |
|---|---|
| Protein Name | Neural cell adhesion molecule L1 |
| Gene Name | L1CAM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 56 | PTDDISLKCEASGKP |
Function
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity
Protein Sequence
10
MVVALRYVWP
20
LLLCSPCLLI
30
QIPEEYEGHH
40
VMEPPVITEQ
50
SPRRLVVFPT
60
DDISLKCEAS
70
GKPEVQFRWT
80
RDGVHFKPKE
90
ELGVTVYQSP
100
HSGSFTITGN
110
NSNFAQRFQG
120
IYRCFASNKL
130
GTAMSHEIRL
140
MAEGAPKWPK
150
ETVKPVEVEE
160
GESVVLPCNP
170
PPSAEPLRIY
180
WMNSKILHIK
190
QDERVTMGQN
200
GNLYFANVLT
210
SDNHSDYICH
220
AHFPGTRTII
230
QKEPIDLRVK
240
ATNSMIDRKP
250
RLLFPTNSSS
260
HLVALQGQPL
270
VLECIAEGFP
280
TPTIKWLRPS
290
GPMPADRVTY
300
QNHNKTLQLL
310
KVGEEDDGEY
320
RCLAENSLGS
330
ARHAYYVTVE
340
AAPYWLHKPQ
350
SHLYGPGETA
360
RLDCQVQGRP
370
QPEVTWRING
380
IPVEELAKDQ
390
KYRIQRGALI
400
LSNVQPSDTM
410
VTQCEARNRH
420
GLLLANAYIY
430
VVQLPAKILT
440
ADNQTYMAVQ
450
GSTAYLLCKA
460
FGAPVPSVQW
470
LDEDGTTVLQ
480
DERFFPYANG
490
TLGIRDLQAN
500
DTGRYFCLAA
510
NDQNNVTIMA
520
NLKVKDATQI
530
TQGPRSTIEK
540
KGSRVTFTCQ
550
ASFDPSLQPS
560
ITWRGDGRDL
570
QELGDSDKYF
580
IEDGRLVIHS
590
LDYSDQGNYS
600
CVASTELDVV
610
ESRAQLLVVG
620
SPGPVPRLVL
630
SDLHLLTQSQ
640
VRVSWSPAED
650
HNAPIEKYDI
660
EFEDKEMAPE
670
KWYSLGKVPG
680
NQTSTTLKLS
690
PYVHYTFRVT
700
AINKYGPGEP
710
SPVSETVVTP
720
EAAPEKNPVD
730
VKGEGNETTN
740
MVITWKPLRW
750
MDWNAPQVQY
760
RVQWRPQGTR
770
GPWQEQIVSD
780
PFLVVSNTST
790
FVPYEIKVQA
800
VNSQGKGPEP
810
QVTIGYSGED
820
YPQAIPELEG
830
IEILNSSAVL
840
VKWRPVDLAQ
850
VKGHLRGYNV
860
TYWREGSQRK
870
HSKRHIHKDH
880
VVVPANTTSV
890
ILSGLRPYSS
900
YHLEVQAFNG
910
RGSGPASEFT
920
FSTPEGVPGH
930
PEALHLECQS
940
NTSLLLRWQP
950
PLSHNGVLTG
960
YVLSYHPLDE
970
GGKGQLSFNL
980
RDPELRTHNL
990
TDLSPHLRYR
1000
FQLQATTKEG
1010
PGEAIVREGG
1020
TMALSGISDF
1030
GNISATAGEN
1040
YSVVSWVPKE
1050
GQCNFRFHIL
1060
FKALGEEKGG
1070
ASLSPQYVSY
1080
NQSSYTQWDL
1090
QPDTDYEIHL
1100
FKERMFRHQM
1110
AVKTNGTGRV
1120
RLPPAGFATE
1130
GWFIGFVSAI
1140
ILLLLVLLIL
1150
CFIKRSKGGK
1160
YSVKDKEDTQ
1170
VDSEARPMKD
1180
ETFGEYRSLE
1190
SDNEEKAFGS
1200
SQPSLNGDIK
1210
PLGSDDSLAD
1220
YGGSVDVQFN
1230
EDGSFIGQYS
1240
GKKEKEAAGG
1250
NDSSGATSPI
NPAVALE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0044295 | axonal growth cone |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008046 | axon guidance receptor activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Biological Process | GO:0061564 | axon development |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0007156 | homophilic cell-cell adhesion |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0050808 | synapse organization |
Reference
PMID: N/A