Search Results
Overview
| Uniprot ID | P32320 |
|---|---|
| Protein Name | Cytidine deaminase |
| Gene Name | CDA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 27 | VCSQEAKKSAYCPYS |
| 73 | AERTAIQKAVSEGYK |
Function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
Protein Sequence
10
MAQKRPACTL
20
KPECVQQLLV
30
CSQEAKKSAY
40
CPYSHFPVGA
50
ALLTQEGRIF
60
KGCNIENACY
70
PLGICAERTA
80
IQKAVSEGYK
90
DFRAIAIASD
100
MQDDFISPCG
110
ACRQVMREFG
120
TNWPVYMTKP
130
DGTYIVMTVQ
140
ELLPSSFGPE
DLQKTQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Molecular Function | GO:0004126 | cytidine deaminase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0001882 | nucleoside binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071217 | cellular response to external biotic stimulus |
| Biological Process | GO:0006248 | CMP catabolic process |
| Biological Process | GO:0019858 | cytosine metabolic process |
| Biological Process | GO:0006249 | dCMP catabolic process |
| Biological Process | GO:0008655 | pyrimidine-containing compound salvage |
| Biological Process | GO:0044206 | UMP salvage |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.