Search Results
Overview
| Uniprot ID | P32322 |
|---|---|
| Protein Name | Pyrroline-5-carboxylate reductase 1, mitochondrial |
| Gene Name | PYCR1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 283 | QVSPAAIKKTILDKV |
Function
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:16730026, PubMed:23024808). Involved in the cellular response to oxidative stress (PubMed:16730026, PubMed:19648921)
Protein Sequence
10
MSVGFIGAGQ
20
LAFALAKGFT
30
AAGVLAAHKI
40
MASSPDMDLA
50
TVSALRKMGV
60
KLTPHNKETV
70
QHSDVLFLAV
80
KPHIIPFILD
90
EIGADIEDRH
100
IVVSCAAGVT
110
ISSIEKKLSA
120
FRPAPRVIRC
130
MTNTPVVVRE
140
GATVYATGTH
150
AQVEDGRLME
160
QLLSSVGFCT
170
EVEEDLIDAV
180
TGLSGSGPAY
190
AFTALDALAD
200
GGVKMGLPRR
210
LAVRLGAQAL
220
LGAAKMLLHS
230
EQHPGQLKDN
240
VSSPGGATIH
250
ALHVLESGGF
260
RSLLINAVEA
270
SCIRTRELQS
280
MADQEQVSPA
290
AIKKTILDKV
300
KLDSPAGTAL
310
SPSGHTKLLP
RSLAPAGKD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:1902792 | pyrroline-5-carboxylate reductase complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004735 | pyrroline-5-carboxylate reductase activity |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0055129 | L-proline biosynthetic process |
| Biological Process | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.