Search Results

Overview

Uniprot ID	P32551
Protein Name	Cytochrome b-c1 complex subunit 2, mitochondrial
Gene Name	Uqcrc2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
108	GIEAVGGKLSVTATR
161	RSQLKIDKAVAFQNP
249	GLGLAGAKAKYRGGE
374	SADVQAAKNKLKAGY
91	LASTLTTKGASSFKI

Function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (By similarity)

Protein Sequence

10 MKLLSRAGSF 20 SRFYSLKVAP 30 KLKTSAPGGV 40 PLQPQELEFT 50 KLPNGLVIAS 60 LENYAPLSRI 70 GLFIKAGSRY 80 ENYNYLGTSH 90 LLRLASTLTT 100 KGASSFKITR 110 GIEAVGGKLS 120 VTATRENMAY 130 TVEGIRDDIE 140 ILMEFLLNVT 150 TAPEFRRWEV 160 AALRSQLKID 170 KAVAFQNPQT 180 RIIENLHDVA 190 YKNALANPLY 200 CPDYRMGKIT 210 SEELHYFVQN 220 HFTSARMALV 230 GLGVSHSILK 240 EVAEQFLNIR 250 GGLGLAGAKA 260 KYRGGEIREQ 270 NGDNLVHAAI 280 VAESAAIGNA 290 EANAFSVLQH 300 LLGAGPHIKR 310 GNNTTSLLSQ 320 SVAKGSQQPF 330 DVSAFNASYS 340 DSGLFGIYTV 350 SQAAAAGDVI 360 NAAYNQVKAV 370 AQGNLSSADV 380 QAAKNKLKAG 390 YLMSVETSEG 400 FLSEIGSQAL 410 ATGSYMPPPT 420 VLQQIDAVAD 430 ADVVKAAKKF 440 VSGKKSMTAS 450 GNLGHTPFLD EL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045275	respiratory chain complex III
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Molecular Function	GO:0044877	protein-containing complex binding
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0022904	respiratory electron transport chain
Biological Process	GO:0009410	response to xenobiotic stimulus

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.