Search Results

Overview

Uniprot IDP32754
Protein Name4-hydroxyphenylpyruvate dioxygenase
Gene NameHPD
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
127 EPWVEQDKFGKVKFA
132 QDKFGKVKFAVLQTY
247 INEPAPGKKKSQIQE
249 EPAPGKKKSQIQEYV
311 KTAKIKVKENIDALE
63 EVVSHVIKQGKIVFV
7 *MTTYSDKGAKPERG
88 EMGDHLVKHGDGVKD

Function

Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism (PubMed:10942115, PubMed:1339442, PubMed:34047349, PubMed:37794595). In addition may act as a N6-methyltransferase that methylates adenosine residues at the N(6) position of some RNAs (PubMed:10942115)

Protein Sequence

10 MTTYSDKGAK 20 PERGRFLHFH 30 SVTFWVGNAK 40 QATSFYCSKM 50 GFEPLAYRGL 60 ETGSREVVSH 70 VIKQGKIVFV 80 LSSALNPWNK 90 EMGDHLVKHG 100 DGVKDIAFEV 110 EDCDYIVQKA 120 RERGAKIMRE 130 PWVEQDKFGK 140 VKFAVLQTYG 150 DTTHTLVEKM 160 NYIGQFLPGY 170 EAPAFMDPLL 180 PKLPKCSLEM 190 IDHIVGNQPD 200 QEMVSASEWY 210 LKNLQFHRFW 220 SVDDTQVHTE 230 YSSLRSIVVA 240 NYEESIKMPI 250 NEPAPGKKKS 260 QIQEYVDYNG 270 GAGVQHIALK 280 TEDIITAIRH 290 LRERGLEFLS 300 VPSTYYKQLR 310 EKLKTAKIKV 320 KENIDALEEL 330 KILVDYDEKG 340 YLLQIFTKPV 350 QDRPTLFLEV 360 IQRHNHQGFG 370 AGNFNSLFKA 380 FEEEQNLRGN 390 LTNMETNGVV PGM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0000139 Golgi membrane
Molecular Function GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0006559 L-phenylalanine catabolic process
Biological Process GO:0006572 L-tyrosine catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.