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Overview

Uniprot IDP32780
Protein NameGeneral transcription factor IIH subunit 1
Gene NameGTF2H1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
206 TYPAVKMKYAENVPH
218 VPHNMTEKEFWTRFF
305 NSNAAIIKRFNHHSA
60 QKISPEGKAKIQLQL
62 ISPEGKAKIQLQLVL

Function

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription

Protein Sequence

10 MATSSEEVLL 20 IVKKVRQKKQ 30 DGALYLMAER 40 IAWAPEGKDR 50 FTISHMYADI 60 KCQKISPEGK 70 AKIQLQLVLH 80 AGDTTNFHFS 90 NESTAVKERD 100 AVKDLLQQLL 110 PKFKRKANKE 120 LEEKNRMLQE 130 DPVLFQLYKD 140 LVVSQVISAE 150 EFWANRLNVN 160 ATDSSSTSNH 170 KQDVGISAAF 180 LADVRPQTDG 190 CNGLRYNLTS 200 DIIESIFRTY 210 PAVKMKYAEN 220 VPHNMTEKEF 230 WTRFFQSHYF 240 HRDRLNTGSK 250 DLFAECAKID 260 EKGLKTMVSL 270 GVKNPLLDLT 280 ALEDKPLDEG 290 YGISSVPSAS 300 NSKSIKENSN 310 AAIIKRFNHH 320 SAMVLAAGLR 330 KQEAQNEQTS 340 EPSNMDGNSG 350 DADCFQPAVK 360 RAKLQESIEY 370 EDLGKNNSVK 380 TIALNLKKSD 390 RYYHGPTPIQ 400 SLQYATSQDI 410 INSFQSIRQE 420 MEAYTPKLTQ 430 VLSSSAASST 440 ITALSPGGAL 450 MQGGTQQAIN 460 QMVPNDIQSE 470 LKHLYVAVGE 480 LLRHFWSCFP 490 VNTPFLEEKV 500 VKMKSNLERF 510 QVTKLCPFQE 520 KIRRQYLSTN 530 LVSHIEEMLQ 540 TAYNKLHTWQ SRRLMKKT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0000439 transcription factor TFIIH core complex
Cellular Component GO:0005675 transcription factor TFIIH holo complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0009755 hormone-mediated signaling pathway
Biological Process GO:0006289 nucleotide-excision repair
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:0006360 transcription by RNA polymerase I
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0006367 transcription initiation at RNA polymerase II promoter

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.