Search Results
Overview
| Uniprot ID | P33124 |
|---|---|
| Protein Name | Long-chain-fatty-acid--CoA ligase 6 |
| Gene Name | Acsl6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 376 | LLNRMYDKIFHQADT |
| 561 | DRKKHIFKLAQGEYV |
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid
Protein Sequence
10
MQTQEILRIL
20
RLPELSDLGQ
30
FFRSLSATTL
40
VSMGALAAIL
50
AYWLTHRPKA
60
LQPPCNLLMQ
70
SEEVEDSGGA
80
RRSVIGDCTQ
90
LLTHYYDDAR
100
TMYQVFRRGL
110
SISGNGPCLG
120
FRKPEQPYQW
130
LSYQEVAKRA
140
EFLGSGLLQH
150
DCKVGTEQFI
160
GVFAQNRPEW
170
IIAELACYTY
180
SMVVVPLYDT
190
LGPGSIRYII
200
NTADICTVIV
210
DKPHKAILLL
220
EHVERKETPG
230
LKLVILMEPF
240
DDALRERGKK
250
CGVDIKSMQA
260
IEDSGQENHR
270
VPVPPRPDDL
280
SIVCFTSGTT
290
GNPKGAMLTH
300
GNVVADFSGF
310
LKVTESQWAP
320
TCADVHFSYL
330
PLAHMFERMV
340
QSVVYCHGGR
350
VGFFQGDIRL
360
LSDDMKALRP
370
TIFPVVPRLL
380
NRMYDKIFHQ
390
ADTSLKRWLL
400
EFAAKRKQAE
410
VRSGIIRNNS
420
IWDELFFNKI
430
QASLGGHVRM
440
IVTGAAPASP
450
TVLGFLRAAL
460
GCQVYEGYGQ
470
TECTAGCTFT
480
TPGDWTSGHV
490
GAPLPCNHIK
500
LVDAEELNYW
510
TSKGEGEICV
520
KGPNVFKGYL
530
KDEDRTKEAL
540
DSDGWLHTGD
550
IGKWLPEGTL
560
KIIDRKKHIF
570
KLAQGEYVAP
580
EKIENIYIRS
590
EPVAQIYVHG
600
DSLKAFLVGI
610
VVPDPEVMPC
620
WAQKKGIEGN
630
YQELCKSKEL
640
KKAILDDMVM
650
LGKESGLHSF
660
EQVKAIYIHC
670
DMFSVQNGLL
680
TPTLKAKRPE
690
LREYFKKQIE
ELYSISM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0004467 | long-chain fatty acid-CoA ligase activity |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Molecular Function | GO:0047676 | arachidonate-CoA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0015908 | fatty acid transport |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process |
| Biological Process | GO:0007405 | neuroblast proliferation |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0008654 | phospholipid biosynthetic process |
| Biological Process | GO:0010747 | positive regulation of long-chain fatty acid import across plasma membrane |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0009629 | response to gravity |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0048545 | response to steroid hormone |
| Biological Process | GO:0019432 | triglyceride biosynthetic process |
| Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.