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Overview

Uniprot IDP33176
Protein NameKinesin-1 heavy chain
Gene NameKIF5B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
240 AGSEKVSKTGAEGAV
67 QVYNDCAKKIVKDVL
690 MEKEHLNKVQTANEV
801 QTLHNLRKLFVQDLA
813 DLATRVKKSAEIDSD

Function

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571)

Protein Sequence

10 MADLAECNIK 20 VMCRFRPLNE 30 SEVNRGDKYI 40 AKFQGEDTVV 50 IASKPYAFDR 60 VFQSSTSQEQ 70 VYNDCAKKIV 80 KDVLEGYNGT 90 IFAYGQTSSG 100 KTHTMEGKLH 110 DPEGMGIIPR 120 IVQDIFNYIY 130 SMDENLEFHI 140 KVSYFEIYLD 150 KIRDLLDVSK 160 TNLSVHEDKN 170 RVPYVKGCTE 180 RFVCSPDEVM 190 DTIDEGKSNR 200 HVAVTNMNEH 210 SSRSHSIFLI 220 NVKQENTQTE 230 QKLSGKLYLV 240 DLAGSEKVSK 250 TGAEGAVLDE 260 AKNINKSLSA 270 LGNVISALAE 280 GSTYVPYRDS 290 KMTRILQDSL 300 GGNCRTTIVI 310 CCSPSSYNES 320 ETKSTLLFGQ 330 RAKTIKNTVC 340 VNVELTAEQW 350 KKKYEKEKEK 360 NKILRNTIQW 370 LENELNRWRN 380 GETVPIDEQF 390 DKEKANLEAF 400 TVDKDITLTN 410 DKPATAIGVI 420 GNFTDAERRK 430 CEEEIAKLYK 440 QLDDKDEEIN 450 QQSQLVEKLK 460 TQMLDQEELL 470 ASTRRDQDNM 480 QAELNRLQAE 490 NDASKEEVKE 500 VLQALEELAV 510 NYDQKSQEVE 520 DKTKEYELLS 530 DELNQKSATL 540 ASIDAELQKL 550 KEMTNHQKKR 560 AAEMMASLLK 570 DLAEIGIAVG 580 NNDVKQPEGT 590 GMIDEEFTVA 600 RLYISKMKSE 610 VKTMVKRCKQ 620 LESTQTESNK 630 KMEENEKELA 640 ACQLRISQHE 650 AKIKSLTEYL 660 QNVEQKKRQL 670 EESVDALSEE 680 LVQLRAQEKV 690 HEMEKEHLNK 700 VQTANEVKQA 710 VEQQIQSHRE 720 THQKQISSLR 730 DEVEAKAKLI 740 TDLQDQNQKM 750 MLEQERLRVE 760 HEKLKATDQE 770 KSRKLHELTV 780 MQDRREQARQ 790 DLKGLEETVA 800 KELQTLHNLR 810 KLFVQDLATR 820 VKKSAEIDSD 830 DTGGSAAQKQ 840 KISFLENNLE 850 QLTKVHKQLV 860 RDNADLRCEL 870 PKLEKRLRAT 880 AERVKALESA 890 LKEAKENASR 900 DRKRYQQEVD 910 RIKEAVRSKN 920 MARRGHSAQI 930 AKPIRPGQHP 940 AASPTHPSAI 950 RGGGAFVQNS 960 QPVAVRGGGG KQV

Gene Ontology

Classification GO ID Description
Cellular Component GO:1904115 axon cytoplasm
Cellular Component GO:0035253 ciliary rootlet
Cellular Component GO:0101004 cytolytic granule membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0032839 dendrite cytoplasm
Cellular Component GO:0005871 kinesin complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0099524 postsynaptic cytosol
Cellular Component GO:0031982 vesicle
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Molecular Function GO:0008574 plus-end-directed microtubule motor activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0099641 anterograde axonal protein transport
Biological Process GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex
Biological Process GO:1990048 anterograde neuronal dense core vesicle transport
Biological Process GO:0007411 axon guidance
Biological Process GO:0051642 centrosome localization
Biological Process GO:0032418 lysosome localization
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0042267 natural killer cell mediated cytotoxicity
Biological Process GO:0043268 positive regulation of potassium ion transport
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0032230 positive regulation of synaptic transmission, GABAergic
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0098987 regulation of modification of synapse structure, modulating synaptic transmission
Biological Process GO:1990049 retrograde neuronal dense core vesicle transport
Biological Process GO:0035617 stress granule disassembly
Biological Process GO:0048489 synaptic vesicle transport
Biological Process GO:0047496 vesicle transport along microtubule

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.