Search Results
Overview
| Uniprot ID | P33198 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NADP], mitochondrial |
| Gene Name | IDH2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 124 | FREPIICKNIPRLVP |
| 135 | RLVPGWTKPITIGRH |
| 149 | HAHGDQYKATDFVVD |
| 162 | VDRAGTFKIVFTPKD |
| 168 | FKIVFTPKDGSSAKQ |
| 225 | STKNTILKAYDGRFK |
| 244 | EIFEKHYKTDFDKYK |
| 249 | HYKTDFDKYKIWYEH |
| 353 | RGLEHRGKLDGNQDL |
| 38 | IWQFIKEKLILPHVD |
| 81 | QKYSVAVKCATITPD |
| 96 | EARVEEFKLKKMWKS |
Function
Plays a role in intermediary metabolism and energy production (PubMed:14512428). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:14512428)
Protein Sequence
10
ARAAARHYAD
20
QRIKVAKPVV
30
EMDGDEMTRI
40
IWQFIKEKLI
50
LPHVDVQLKY
60
FDLGLPNRDQ
70
TNDQVTIDSA
80
LATQKYSVAV
90
KCATITPDEA
100
RVEEFKLKKM
110
WKSPNGTIRN
120
ILGGTVFREP
130
IICKNIPRLV
140
PGWTKPITIG
150
RHAHGDQYKA
160
TDFVVDRAGT
170
FKIVFTPKDG
180
SSAKQWEVYN
190
FPAGGVGMGM
200
YNTDESISGF
210
AHSCFQYAIQ
220
KKWPLYMSTK
230
NTILKAYDGR
240
FKDIFQEIFE
250
KHYKTDFDKY
260
KIWYEHRLID
270
DMVAQVLKSS
280
GGFVWACKNY
290
DGDVQSDILA
300
QGFGSLGLMT
310
SVLVCPDGKT
320
IEAEAAHGTV
330
TRHYREHQKG
340
RPTSTNPIAS
350
IFAWTRGLEH
360
RGKLDGNQDL
370
IRFAQTLEKV
380
CVETVESGAM
390
TKDLAGCIHG
400
LSNVKLNEHF
410
LNTSDFLDTI
420
KSNLDRALGR
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004450 | isocitrate dehydrogenase (NADP+) activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0006103 | 2-oxoglutarate metabolic process |
| Biological Process | GO:0006097 | glyoxylate cycle |
| Biological Process | GO:0006102 | isocitrate metabolic process |
| Biological Process | GO:0006739 | NADP+ metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.