Search Results

Overview

Uniprot ID	P33241
Protein Name	Lymphocyte-specific protein 1
Gene Name	LSP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
217	EKSNSVKKSQPDLPI
284	AAKTPSCKDIVAGDM
300	KKSLWEQKGGSKTSS
310	SKTSSTIKSTPSGKR
316	IKSTPSGKRYKFVAT
319	TPSGKRYKFVATGHG
327	FVATGHGKYEKVLVE

Function

May play a role in mediating neutrophil activation and chemotaxis

Protein Sequence

10 MAEASSDPGA 20 EEREELLGPT 30 AQWSVEDEEE 40 AVHEQCQHER 50 DRQLQAQDEE 60 GGGHVPERPK 70 QEMLLSLKPS 80 EAPELDEDEG 90 FGDWSQRPEQ 100 RQQHEGAQGA 110 LDSGEPPQCR 120 SPEGEQEDRP 130 GLHAYEKEDS 140 DEVHLEELSL 150 SKEGPGPEDT 160 VQDNLGAAGA 170 EEEQEEHQKC 180 QQPRTPSPLV 190 LEGTIEQSSP 200 PLSPTTKLID 210 RTESLNRSIE 220 KSNSVKKSQP 230 DLPISKIDQW 240 LEQYTQAIET 250 AGRTPKLARQ 260 ASIELPSMAV 270 ASTKSRWETG 280 EVQAQSAAKT 290 PSCKDIVAGD 300 MSKKSLWEQK 310 GGSKTSSTIK 320 STPSGKRYKF 330 VATGHGKYEK VLVEGGPAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0003779	actin binding
Biological Process	GO:0006968	cellular defense response
Biological Process	GO:0007165	signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.