Overview
| Uniprot ID | P33316 |
|---|
| Protein Name | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
|---|
| Gene Name | DUT |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 179 |
PRSGLAAKHFIDVGA |
Function
Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity)
Protein Sequence
10
MTPLCPRPAL
20
CYHFLTSLLR
30
SAMQNARGAR
40
QRAEAAVLSG
50
PGPPLGRAAQ
60
HGIPRPLSSA
70
GRLSQGCRGA
80
STVGAAGWKG
90
ELPKAGGSPA
100
PGPETPAISP
110
SKRARPAEVG
120
GMQLRFARLS
130
EHATAPTRGS
140
ARAAGYDLYS
150
AYDYTIPPME
160
KAVVKTDIQI
170
ALPSGCYGRV
180
APRSGLAAKH
190
FIDVGAGVID
200
EDYRGNVGVV
210
LFNFGKEKFE
220
VKKGDRIAQL
230
ICERIFYPEI
240
EEVQALDDTE
250
RGSGGFGSTG
KN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0004170 |
dUTP diphosphatase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0042975 |
peroxisome proliferator activated receptor binding |
| Molecular Function |
GO:0032556 |
pyrimidine deoxyribonucleotide binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0030547 |
signaling receptor inhibitor activity |
| Biological Process |
GO:0006260 |
DNA replication |
| Biological Process |
GO:0006231 |
dTMP biosynthetic process |
| Biological Process |
GO:0006226 |
dUMP biosynthetic process |
| Biological Process |
GO:0046081 |
dUTP catabolic process |
| Biological Process |
GO:0001889 |
liver development |
| Biological Process |
GO:0006139 |
nucleobase-containing compound metabolic process |
| Biological Process |
GO:0043254 |
regulation of protein-containing complex assembly |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.